May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Advanced Glycataion End Products (AGEs) in human lens capsules
J. Dawczynski; M. Kasper; S. Franke; E. Königsdörffer; R. Augsten; J. Strobel
Author Affiliations & Notes
  • J. Dawczynski
    Ophthalmology,
    Friedrich–Schiller Univ, Jena, Germany
  • M. Kasper
    Anatomy, University of Dresden, Dresden, Germany
  • S. Franke
    Internal Medicine,
    Friedrich–Schiller Univ, Jena, Germany
  • E. Königsdörffer
    Ophthalmology,
    Friedrich–Schiller Univ, Jena, Germany
  • R. Augsten
    Ophthalmology,
    Friedrich–Schiller Univ, Jena, Germany
  • J. Strobel
    Ophthalmology,
    Friedrich–Schiller Univ, Jena, Germany
  • Footnotes
    Commercial Relationships  J. Dawczynski, None; M. Kasper, None; S. Franke, None; E. Königsdörffer, None; R. Augsten, None; J. Strobel, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1707. doi:
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      J. Dawczynski, M. Kasper, S. Franke, E. Königsdörffer, R. Augsten, J. Strobel; Advanced Glycataion End Products (AGEs) in human lens capsules . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1707.

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Abstract

Abstract: : Purpose: Advanced Glycation End Products (AGEs) are involved in many pathobiochemical pathways. The focus of this study was to examine the role of different AGEs in the pathogenesis of cataract formation. Methods:26 human lens capsules (13 diabetic and 13 non–diabetic)were investigated. The immunohistochemical localisation of the AGEs carboxymethyllysine (CML) and pentosidine were performed at these lens capsulues. Results: In nearly alle lens capsules AGEs could be localized. However, diabetic patients showed a much higher immunoreactivity for CML and pentosidine compared to non–diabetic subjects. Conclusions:Different AGEs are present in human lens capsules. Differences could be shown between diabetic and non–diabetic subjects and AGEs might be involved in the complex process of lens opacification.

Keywords: cataract • aging • oxidation/oxidative or free radical damage 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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