May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The relationship between the glycosylated hemoglobin and the anterior lens capsule thickness in diabetic patients
Author Affiliations & Notes
  • S. Bakalian
    Ocular Pathology,
    McGill University, Montreal, PQ, Canada
  • W.E. S. Connolly
    Ophthalmology,
    McGill University, Montreal, PQ, Canada
  • S. Lindley
    Ophthalmology,
    McGill University, Montreal, PQ, Canada
  • E. Antecka
    Ocular Pathology,
    McGill University, Montreal, PQ, Canada
  • S.A. Callejo
    Ocular Pathology,
    McGill University, Montreal, PQ, Canada
  • R.N. G. Vianna
    Ophthalmology,
    McGill University, Montreal, PQ, Canada
  • M.N. Burnier, Jr.
    Ocular Pathology,
    McGill University, Montreal, PQ, Canada
  • Footnotes
    Commercial Relationships  S. Bakalian, None; W.E.S. Connolly, None; S. Lindley, None; E. Antecka, None; S.A. Callejo, None; R.N.G. Vianna, None; M.N. Burnier Jr., None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1708. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S. Bakalian, W.E. S. Connolly, S. Lindley, E. Antecka, S.A. Callejo, R.N. G. Vianna, M.N. Burnier, Jr.; The relationship between the glycosylated hemoglobin and the anterior lens capsule thickness in diabetic patients . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1708.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Our previous report has shown that diabetes increases the thickness of the anterior capsule basement membrane (ACBM), which correlates with the age of the patient and duration of the disease as opposed to non diabetic patients. The purpose of this study is to establish the relationship between the increasing thickness of the ACBM and glycosylated hemoglobin (HbA1c) levels in diabetic patients (DP). Methods: In this prospective randomized study, anterior lens capsule specimens were collected from routine phaco–emulsification cataract surgeries with capsulorexis, performed by two surgeons using the same equipments and techniques. Thirty lens capsule specimens of DP were formalin–fixed and paraffin–embedded and stained with H&E and periodic acid–Schiff (PAS). The cases were reviewed under a light microscope at 40x magnification. The ACBM thickness was measured, in units (u), using a Carl–Zeis 444034 eyepiece. The duration of diabetes, the age of the patient, and HbA1c levels were recorded. The diabetic patients have been divided into two groups according to the duration of the disease, D1 < 10 years, D2 > 10 years. D1 and D2 were further sub divided into three groups according to their HbA1c levels; group one (G1) < 7.0%, group two (G2) 7.0%–9.0%, group three (G3) > 9.0%. Results: For all cases of DP, the mean (M) age was 73.1, the M level of HbA1c was 7.59%, and the M thickness of the ACBM was 11.24u. Our results showed that there was an apparent relationship between the increasing thickness of the ACBM and the increasing levels of the HbA1c for both the D1 and D2 groups. For D1 group the results were; G1 subgroup (the M age=73.1, the M thickness =11u, and the M level of HbA1c=6.55%); G2 subgroup (the M age=73, the M thickness=11.13u, and the M level of HbA1c =7.92%); G3 subgroup (the M age=76.5, the M thickness=12.5u, and the M level of HbA1c=11.3%). For D2 group the results were; G1 subgroup (the M age=71.7, the M thickness=9.3, and the M level of HbA1c=6.3%); G2 subgroup (the M age=72.4, the M thickness=11.8u, and the M level of HbA1c=7.62%); G3 subgroup (the M age=76, the M thickness=13u, and the M level of HbA1c=12.5%). Conclusions: Our results showed that with the increasing levels of HbA1c the ACBM thickness was increased in both D1 and D2 groups of DP, which means that the increasing level of HbA1c may play a role in increased thickness of the ACBM of DP. Further studies with more samples should be performed in order to determine the exact role of the HbA1c and correlate it with the duration of the disease and the thickness of the ACBM in DP.

Keywords: diabetes • cataract 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×