May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Effect of Phenylephrine 5% eyedrops on refraction and accommodation in phakic eyes
Author Affiliations & Notes
  • N.X. Nguyen
    Department of Ophthalmology, University of Erlangen–Nürnberg, Erlangen, Erlangen, Germany
  • A. Ribhegge
    Department of Ophthalmology, University of Erlangen–Nürnberg, Erlangen, Erlangen, Germany
  • S. Reese
    Department of Ophthalmology, University of Erlangen–Nürnberg, Erlangen, Erlangen, Germany
  • A. Langenbucher
    Department of Ophthalmology, University of Erlangen–Nürnberg, Erlangen, Erlangen, Germany
  • B. Seitz
    Department of Ophthalmology, University of Erlangen–Nürnberg, Erlangen, Erlangen, Germany
  • Footnotes
    Commercial Relationships  N.X. Nguyen, None; A. Ribhegge, None; S. Reese, None; A. Langenbucher, None; B. Seitz, None.
  • Footnotes
    Support  LGA–TP87c
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1743. doi:
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      N.X. Nguyen, A. Ribhegge, S. Reese, A. Langenbucher, B. Seitz; Effect of Phenylephrine 5% eyedrops on refraction and accommodation in phakic eyes . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1743.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: There is considerable development in new surgical procedures and posterior chamber lenses aimed at restoring accommodation in presbyopia. However, restoration of accommodation is only feasible, if the non–lenticular parts of the accommodative apparatus remain functional. Aim of this study was to assess refraction and accommodation amplitude in phakic eyes under pupil dilation with phenylephrine 5% eye drops (Neosynephrin–POS 5%). Methods: 52 healthy subjects, age 18–76 (mean age 38 yrs) were included in this study. Two drops of phenylephrine 5% were instilled at a intervall of 5 minutes in one eye of all subjects according to a randomization list. Complete examination at baseline and 30 minutes post–treament included: Distance refraction (spherical equivalent SEQ) in diopters (D), best–corrected distance visual acuity (DVA), near visual acuity (Birkhäuser charts in 35 cm, NVA), subjective near point obtained with an accommodometer (Clement–Clark, NP), accommodative range measured by near point (AR), anterior chamber depth (ACD) and lens thickness (LT) determined with Zeiss IOL–Master. Results: Pupil size was 4.3±0.3 mm at baseline and 7.5±0.5mm at 30 minutes after medication. At baseline/30 minutes after phenylephrine 5% medication: SEQ was –0.5D/–0.5 (D), DVA was 1.0/1.0, NVA was 1.0/0.9, NP was 20cm/22cm, AR was 6.15D/5.5D, ACD was 3.57mm/3.64mm and LT was 3.91mm/4.0mm. There were no significant differences for any parameters tested before and after pharmacologic stimulation. Conclusion: Using various subjective and objective methods we could demonstrate that phenylphrine 5% eye drops do not significantly affect the accommodation in phakic eyes. This findings confirm that this drug causes pupil dilation without contracting the ciliary muscle. Support: Bayerisches Förderprogramm "Leitprojekt Medizintechnik" (LGA–TP87c)

Keywords: clinical research methodology • drug toxicity/drug effects • ciliary muscle 
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