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H. Bando, Y. Ikuno, J.S. Choi, I. Yamanaka, T. Ishibasi, Y. Tano; Ultrastructure of Internal Limiting Membrane in Myopic Foveoschisis . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2037.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: In order to reveal the pathogenesis of foveoschisis associated with high myopia, we studied the ultrastructure of surgically removed internal limiting membrane (ILM) of these eyes. Methods: ILMs were collected from ten patients with myopic foveoschisis (MF) and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics and thickness of the ILM were compared between the two groups. Results:Collagen fiber and cell dsebris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P<0.05) than found in IMH subjects (0%). More fibrous glial cell was likely to be found on the inner surface of ILM in MF. No significant difference in fibroblast–like cell adhesion or ILM thickness was observed. Conclusion: Collagen fiber and cellular component are suggested to play an important role in developing foveoschisis in high myopia. ILM peeling may be essential for vitrectomy for MF.
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