May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Ultrastructure of Internal Limiting Membrane in Myopic Foveoschisis
H. Bando; Y. Ikuno; J.S. Choi; I. Yamanaka; T. Ishibasi; Y. Tano
Author Affiliations & Notes
  • H. Bando
    Ophthalmology, Osaka University, Suita, Japan
  • Y. Ikuno
    Ophthalmology, Osaka University, Suita, Japan
  • J.S. Choi
    Ophthalmology, Osaka University, Suita, Japan
  • I. Yamanaka
    Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • T. Ishibasi
    Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Y. Tano
    Ophthalmology, Osaka University, Suita, Japan
  • Footnotes
    Commercial Relationships  H. Bando, None; Y. Ikuno, None; J.S. Choi, None; I. Yamanaka, None; T. Ishibasi, None; Y. Tano, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2037. doi:
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      H. Bando, Y. Ikuno, J.S. Choi, I. Yamanaka, T. Ishibasi, Y. Tano; Ultrastructure of Internal Limiting Membrane in Myopic Foveoschisis . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2037.

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Abstract

Abstract: : Purpose: In order to reveal the pathogenesis of foveoschisis associated with high myopia, we studied the ultrastructure of surgically removed internal limiting membrane (ILM) of these eyes. Methods: ILMs were collected from ten patients with myopic foveoschisis (MF) and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics and thickness of the ILM were compared between the two groups. Results:Collagen fiber and cell dsebris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P<0.05) than found in IMH subjects (0%). More fibrous glial cell was likely to be found on the inner surface of ILM in MF. No significant difference in fibroblast–like cell adhesion or ILM thickness was observed. Conclusion: Collagen fiber and cellular component are suggested to play an important role in developing foveoschisis in high myopia. ILM peeling may be essential for vitrectomy for MF.

Keywords: myopia • retina • macula/fovea 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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