May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Patterns of Visual Field Abnormalities in Normal versus High Tension Glaucoma
Author Affiliations & Notes
  • D.H. Chu
    New York University School of Medicine, New York, NY
  • V.C. Greenstein
    Ophthalmology,
    Columbia University, New York, NY
    Ophthalmology, New York University, New York, NY
  • P. Thienprasiddhi
    New York Eye and Ear Infirmary, New York, NY
  • J.M. Liebmann
    New York University School of Medicine, New York, NY
    Manhattan Eye, Ear, and Throat Hospital, New York, NY
  • D.C. Hood
    Psychology,
    Columbia University, New York, NY
  • R. Ritch
    New York Eye and Ear Infirmary, New York, NY
  • Footnotes
    Commercial Relationships  D.H. Chu, None; V.C. Greenstein, None; P. Thienprasiddhi, None; J.M. Liebmann, None; D.C. Hood, None; R. Ritch, None.
  • Footnotes
    Support  NIH Grant EY02115
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2133. doi:
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      D.H. Chu, V.C. Greenstein, P. Thienprasiddhi, J.M. Liebmann, D.C. Hood, R. Ritch; Patterns of Visual Field Abnormalities in Normal versus High Tension Glaucoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2133.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: The existence of different patterns of visual field deficits in normal–tension (NTG) and high–tension (HTG) glaucoma is controversial. Here we compare the visual field results obtained from patients with either NTG or HTG using both the multifocal visual evoked potential (mfVEP) and achromatic automated perimetry (AAP) techniques. Methods: Thirty–two patients with NTG (maximum recorded IOP ≤21 mmHg) and 45 with HTG (IOP ≥22 mmHg) were studied. All patients had reliable Humphrey visual fields (HVF) with a mean deviation of better than –10 dB in both eyes, and glaucomatous damage in at least one eye, as defined by a glaucomatous optic disc and an abnormal HVF (PSD<5% and/or GHT outside normal limits). Monocular mfVEPs were obtained from each eye using a pattern–reversal dartboard array, 44.5 degrees in diameter, and containing 60 sectors. The mfVEPs were obtained using VERIS (EDI), three channels of recording, and monocular probability plots analyzed with custom software [1,2]. If both eyes qualified, one eye was selected at random. Both hemifields from each eye were separated into a central 10 degree (radius) area and an outer arcuate area. The mfVEP and HVF probability plots within each area were defined as abnormal based on the following cluster test: either at least two contiguous points at p<0.01, or at least three contiguous points at p<0.05 with one point at p<0.01. The average number of points at the p<0.05 and p<0.01 levels of significance within the central areas was also calculated. The data were analyzed with the chi–square test and Student t–test. Results:22 (69%) NTG eyes and 20 (44%) HTG eyes had abnormal clusters in the central 10 degree area of the superior hemifield on mfVEP plots, and 21 (66%) NTG eyes and 13 (29%) HTG eyes had abnormal clusters in the same area on HVF plots. These differences were both statistically significant. NTG eyes also had significantly more depressed points in the same area on both mfVEP and HVF. There was no significant difference between the NTG and HTG groups in the central 10 degree area of the inferior hemifield, nor in the arcuate area in either superior or inferior hemifield. Conclusions: The pattern of visual field damage differs in NTG and HTG in the superior, central hemifield. 1. Hood et al (2002) AO. 2. Hood and Greenstein (2003) Prog Ret Eye Res.

Keywords: electrophysiology: clinical • visual fields • perimetry 
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