May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The Accommodative Apparatus In The Aging Rhesus Monkey
Author Affiliations & Notes
  • M.A. Croft
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • A. Glasser
    College of Optometry, Univ of Houston, Houston, TX
  • J. McDonald
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • E. Vinje
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • R. James
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • B. Gabelt
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • G.A. Heatley
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • P.L. Kaufman
    Ophthalmology Visual Science, Univ of Wisconsin Madison, Madison, WI
  • Footnotes
    Commercial Relationships  M.A. Croft, None; A. Glasser, None; J. McDonald, None; E. Vinje, None; R. James, None; B. Gabelt, None; G.A. Heatley, None; P.L. Kaufman, None.
  • Footnotes
    Support  NEI (EY10213), RPB, OPREF.
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2187. doi:
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      M.A. Croft, A. Glasser, J. McDonald, E. Vinje, R. James, B. Gabelt, G.A. Heatley, P.L. Kaufman; The Accommodative Apparatus In The Aging Rhesus Monkey . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2187.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To further elucidate the functional interaction of the accommodative structures and their change with age in rhesus monkeys. Methods:Accommodation was studied in 26 rhesus monkeys, aged 6–24 yr, using central stimulation of the E–W nucleus. Accommodative amplitude was measured by coincidence refractometry. Goniovideography and ultrasound biomicroscopy (UBM 50MHz) were performed before and after intra– and extra–capsular lens extraction (ICLE, ECLE). Centripetal lens/capsule and ciliary process (CP) movements were measured by computerized image analysis. UBM at 35 and 20 MHz was used to visualize ciliary body nasal and temporal quadrants and anterior and posterior lens surfaces in one image. Images of the entire globe were also obtained. Results:During accommodation, the relationship between lens and CP movement in the young (6–10yrs) monkey was 0.87±0.008 (n=6, r=0.99) but 0.46±0.02 (n=16, r=0.97 in the older monkey eyes (17–24yrs). At maximum accommodative stimulation, CP and lens centripetal movement were significantly correlated with accommodation (p<0.001, n=28, age 6–24yr). At supramaximal stimulation, temporal CP movement amplitude increased & was not significantly correlated with maximum accommodation (p<0.16). Following ICLE, CP movement amplitude decreased by 0.11±0.03 mm (n=3). Following ECLE, CP movement amplitude increased by 0.12±0.03 mm (n=4; age 6, 9, 21, 23). The lens thickened and the posterior end of the ciliary body and Bruch's membrane moved forward during accommodation. Conclusions:Lens/CP movement diminished with age by ∼48%. Centripetal CP and lens movement depends on the presence or absence of the lens substance and capsule. Older CP can move more than required to induce maximum accommodation.

Keywords: aging • ciliary body • Bruch's membrane 
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