May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The Role of the Basal Ganglia during Free–Viewing Natural Time–Varying Images
Author Affiliations & Notes
  • D.W. Dong
    Complex Systems & Brain Sciences, Florida Atlantic University, Boca Raton, FL
  • T.G. Weyand
    Cell Biology & Anatomy,
    Louisiana State University Medical Center, New Orleans, LA
  • J. Rao
    Neurology,
    Louisiana State University Medical Center, New Orleans, LA
  • B. Payne
    Neurosurgery,
    Louisiana State University Medical Center, New Orleans, LA
  • Footnotes
    Commercial Relationships  D.W. Dong, None; T.G. Weyand, None; J. Rao, None; B. Payne, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2323. doi:
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      D.W. Dong, T.G. Weyand, J. Rao, B. Payne; The Role of the Basal Ganglia during Free–Viewing Natural Time–Varying Images . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2323.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: It is well–known that diseases in basil ganglia result in perturbations in ocular motor control. Whereas significant efforts have been invested in documenting many characteristics of oculomotor control in such patients, they have been largely restricted to laboratory tasks, i.e., tasks designed to characterize oculomotor parameters under conditions that are not representative of the conditions dictating eye movements in real life. In the current research, we want to study the role of the basil ganglia in gaze control under natural viewing conditions. Methods: We track the eye movements of Parkinsons Disease (PD) patients during free–viewing natural time–varying images. Among the PD patients we have access to are those that are receiving deep–brain stimulation (DBS) to the subthalamic nucleus and inner sector of the globus pallidus. We measure the statistics of eye movements in these individuals, with and without DBS, and compare them with normal controls ––– free–viewing the same natural time–varing images. Such experiments provide direct information on the involvement of the basal ganglia in gaze control. Results:Normal controls exhibit characteristic eye movements during free–viewing natural time–varying images (Dong 2001, ARVO). When the DBS is turned on and properly adjusted, the eye movement statistics of PD patients are similar to controls. When the DBS is turned off, PD patients generate different eye movement statistics from controls. In particular, without DBS, PD patients initiate less number of saccades, generate smaller amplitude of saccades, and keep gaze near one location for a longer time. Conclusions: Under natural viewing conditions, the basil ganglia plays a crucial role in initiating and regulating the saccadic eye movements. The statistics of the eye movements including the fixation time and the number and the amplitude of saccades might be used as sensitive indicators of PD status.

Keywords: ocular motor control • eye movements: saccades and pursuits 
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