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N. Izumi, T. Nagaoka, E. Sato, F. Mori, A. Yoshida; DE–085 Increases Retinal Blood Flow. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2340.
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Purpose: DE–085 is a new prostaglandin derivative. We evaluated the effects of DE–085 on intraocular pressure (IOP) and retinal blood flow (RBF). Methods: Six adult cats were used in this study. After the animals were anesthetized with enflurane and mechanically ventilated, one drop of DE–085 was placed in one eye and nothing in the fellow eye. We measured IOP, vessel diameter, and blood velocity simultaneously before and 30 and 60 minutes after dosing and calculated RBF with a laser Doppler velocimetry system (CLBF model 100, Canon, Tokyo, Japan). Results: The mean (Â±SE) of IOP, vessel diameter, blood velocity, and RBF before dosing were 18.1Â±1.7 mmHg, 89.1Â±3.6 Âµm, 25.2Â±2.2 mm/sec, and 4.6Â±1.1 Âµl/min, respectively. The mean IOP reductions were 2.9 and 3.9 mmHg (16.1% and 21.0%, P<0.05 for each), 30 and 60 minutes after dosing, respectively. The mean vessel diameter increases were 1.0% and 2.4%, 30 and 60 minutes after dosing, respectively. The mean blood velocity increases were 17.4% and 13.7%, 30 and 60 minutes after dosing, respectively. The mean RBF increases were 20.7% and 18.8% (P<0.05 for each), 30 and 60 minutes after dosing, respectively. Conclusions: DE–085 reduces IOP and increases RBF.
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