May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
DE–085 Increases Retinal Blood Flow.
Author Affiliations & Notes
  • N. Izumi
    Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  • T. Nagaoka
    Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  • E. Sato
    Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  • F. Mori
    Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  • A. Yoshida
    Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  • Footnotes
    Commercial Relationships  N. Izumi, None; T. Nagaoka, None; E. Sato, None; F. Mori, None; A. Yoshida, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2340. doi:
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    • Get Citation

      N. Izumi, T. Nagaoka, E. Sato, F. Mori, A. Yoshida; DE–085 Increases Retinal Blood Flow. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2340.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: DE–085 is a new prostaglandin derivative. We evaluated the effects of DE–085 on intraocular pressure (IOP) and retinal blood flow (RBF). Methods: Six adult cats were used in this study. After the animals were anesthetized with enflurane and mechanically ventilated, one drop of DE–085 was placed in one eye and nothing in the fellow eye. We measured IOP, vessel diameter, and blood velocity simultaneously before and 30 and 60 minutes after dosing and calculated RBF with a laser Doppler velocimetry system (CLBF model 100, Canon, Tokyo, Japan). Results: The mean (±SE) of IOP, vessel diameter, blood velocity, and RBF before dosing were 18.1±1.7 mmHg, 89.1±3.6 µm, 25.2±2.2 mm/sec, and 4.6±1.1 µl/min, respectively. The mean IOP reductions were 2.9 and 3.9 mmHg (16.1% and 21.0%, P<0.05 for each), 30 and 60 minutes after dosing, respectively. The mean vessel diameter increases were 1.0% and 2.4%, 30 and 60 minutes after dosing, respectively. The mean blood velocity increases were 17.4% and 13.7%, 30 and 60 minutes after dosing, respectively. The mean RBF increases were 20.7% and 18.8% (P<0.05 for each), 30 and 60 minutes after dosing, respectively. Conclusions: DE–085 reduces IOP and increases RBF.

Keywords: drug toxicity/drug effects 
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