May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Adaptive Optics Ultrahigh Resolution Optical Coherence Tomography
Author Affiliations & Notes
  • W. Drexler
    University Vienna, Department of Medical Physics, Vienna, Austria
  • E.J. Fernandez
    Universidad de Murcia, Campus de Espinardo, Laboratorio de Óptica, Murcia, Spain
  • B. Hermann
    University Vienna, Department of Medical Physics, Vienna, Austria
  • A. Unterhuber
    University Vienna, Department of Medical Physics, Vienna, Austria
  • H. Sattmann
    University Vienna, Department of Medical Physics, Vienna, Austria
  • P.M. Prieto
    Universidad de Murcia, Campus de Espinardo, Laboratorio de Óptica, Murcia, Spain
  • A.F. Fercher
    University Vienna, Department of Medical Physics, Vienna, Austria
  • P. Artal
    Universidad de Murcia, Campus de Espinardo, Laboratorio de Óptica, Murcia, Spain
  • Footnotes
    Commercial Relationships  W. Drexler, Carl Zeiss Meditec Inc. C; Femtloasers C; E.J. Fernandez, None; B. Hermann, None; A. Unterhuber, None; H. Sattmann, None; P.M. Prieto, None; A.F. Fercher, Carl Zeiss Meditec C; P. Artal, None.
  • Footnotes
    Support  FWFY159–PAT,Christian Doppler Society, FEMTOLASERS,CARL ZEISS Meditec,MCyTBFM–001–0391,HU2002–0011
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2384. doi:
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      W. Drexler, E.J. Fernandez, B. Hermann, A. Unterhuber, H. Sattmann, P.M. Prieto, A.F. Fercher, P. Artal; Adaptive Optics Ultrahigh Resolution Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2384.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To demonstrate for the first time the combination of ultrahigh resolution optical coherence tomography (UHR OCT) and adaptive optics (AO) for high axial and transverse resolution in vivo retinal imaging. Methods: A compact (30 x 30 cm) closed–loop adaptive optics system, based on a real–time Hartmann–Shack wave–front sensor at 30 Hz and a 37 element low–cost micromachined membrane deformable mirror (OKO Tech, Holland), was interfaced to an UHR OCT system, based on a commercially available OCT 1 (Carl Zeiss Meditec Inc., CA, Dublin) instrument, employing a compact Titanium:sapphire laser with 130 nm optical bandwidth centered at 800 nm. Results: Adaptive optics ultrahigh resolution OCT enabled unprecedented identification of intraretinal layers in vivo with 3 µm axial resolution. Closed–loop correction of ocular aberrations was accomplished with a residual uncorrected wave–front of 0.1 µm for a 3.68 mm pupil diameter. Strehl ratio improvements of a factor of 10 or more were achieved. A significant UHR OCT signal to noise ratio improvement of up to 9 dB using AO, as compared to uncorrected ocular aberrations, was obtained. AO UHR OCT enabled a transverse resolution of 5–10 µm. This is a 2–3 time improvement as compared to UHR OCT systems used so far, that employed a 1 mm beam diameter without AO. Preliminary results on healthy normal subjects as well as selected patients are presented and further potential technical improvements are discussed. Conclusions: Adaptive optics and ultrahigh resolution OCT has been combined, according to our knowledge, for the first time, demonstrating the potential to increase sensitivity and to enable retinal imaging with 3 µm axial and up to 5 µm transverse resolution. Further technical improvements might enable the three dimensional visualization of retinal features like photoreceptors or capillaries.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • photoreceptors 
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