May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Optic Nerve Measurements in Normal Human Eyes by MRI
Author Affiliations & Notes
  • J.D. Benevento
    Ophthalmology,
    New York Eye & Ear Infirmary, New York, NY
  • J.P. S. Garcia
    Ophthalmology,
    New York Eye & Ear Infirmary, New York, NY
    Ophthalmology, New York Medical College, Valhalla, NY
  • A.B. Baxter
    Radiology,
    New York Eye & Ear Infirmary, New York, NY
  • P.M. T. Garcia
    Ophthalmology,
    New York Eye & Ear Infirmary, New York, NY
    Ophthalmology, New York Medical College, Valhalla, NY
  • R.A. Holliday
    Radiology,
    New York Eye & Ear Infirmary, New York, NY
  • R.B. Rosen
    Ophthalmology,
    New York Eye & Ear Infirmary, New York, NY
  • Footnotes
    Commercial Relationships  J.D. Benevento, None; J.P.S. Garcia, None; A.B. Baxter, None; P.M.T. Garcia, None; R.A. Holliday, None; R.B. Rosen, None.
  • Footnotes
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Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2398. doi:
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      J.D. Benevento, J.P. S. Garcia, A.B. Baxter, P.M. T. Garcia, R.A. Holliday, R.B. Rosen; Optic Nerve Measurements in Normal Human Eyes by MRI . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2398.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To determine the range of optic nerve diameters in normal human eyes using MRI coronal scans. Methods:MRI images of 14 Radiology patients who had undergone MRI of the face or brain for non–ophthalmologic reasons were retrospectively evaluated. Using T1 and T2 weighted coronal scans, the shortest apparent measurement of ONSD and OND were measured 3mm behind the globe by consensus opinion of two investigators. Those with clinical findings of ocular or systemic disease that could reasonably affect the optic nerve diameter were excluded from the study. Data were sorted by age and sex, and then analyzed using Excel and GraphPad Prism 3.03 statistical software. Results:MRI Images of 14 patients (7 males, 7 females) were reviewed. Age ranged from 36 to 78 years. Of the 28 orbits evaluated, ONSD could be measured in all cases, while OND was measurable in 19 (68% of eyes). Mean ONSD was 4.9mm (range: 4.0 – 6.0) SD 0.5mm. Mean ONSD was 5.0mm in males SD 0.6mm, and 4.9mm SD 0.5mm in females. Mean ONSD was 4.9mm SD 0.6mm in subjects younger than 50 years old, and 5.0mm SD 0.5mm in subjects 50 and over. Mean OND was 3.1mm (range: 2.6 – 4.0) SD 0.3mm. Mean OND was 3.1mm in males SD 0.2mm, and 3.1mm SD 0.5mm in females. Mean OND was 3.3mm SD 0.4mm in subjects younger than 50 years old, and 3.0mm SD 0.3mm in subjects 50 and over. Conclusions:Coronal MRI imaging of normal human eyes showed an average ONSD range of 4.0 – 6.0 with SD 0.5mm, and an average OND range of 2.6 – 4.0 with SD 0.3mm. Our range is consistent with published data on the ONSD. However, we are not aware of any published data on the OND. More precise measurements may be possible using dedicated multi–plane high resolution MRI images from larger sample size normal volunteers.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • neuro–ophthalmology: optic nerve • imaging/image analysis: clinical 
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