May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Correlates of Structural and Functional Imaging in the detection of uveitis–induced Cystoid Macular Edema
S.G. Coupland; W.G. Hodge; B.C. Leonard; P.J. Kertes; A. Bhargava; W.R. Lamba
Author Affiliations & Notes
  • S.G. Coupland
    Eye Institute,
    University of Ottawa, Ottawa, ON, Canada
  • W.G. Hodge
    Eye Institute,
    University of Ottawa, Ottawa, ON, Canada
  • B.C. Leonard
    Eye Institute,
    University of Ottawa, Ottawa, ON, Canada
  • P.J. Kertes
    Dept of Ophthalmology, Sunnybrook and Womens' Hospital, Toronto, ON, Canada
  • A. Bhargava
    Eye Institute,
    University of Ottawa, Ottawa, ON, Canada
  • W.R. Lamba
    School of Medicine,
    University of Ottawa, Ottawa, ON, Canada
  • Footnotes
    Commercial Relationships  S.G. Coupland, None; W.G. Hodge, None; B.C. Leonard, None; P.J. Kertes, None; A. Bhargava, None; W.R. Lamba, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2401. doi:
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      S.G. Coupland, W.G. Hodge, B.C. Leonard, P.J. Kertes, A. Bhargava, W.R. Lamba; Correlates of Structural and Functional Imaging in the detection of uveitis–induced Cystoid Macular Edema . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2401.

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Abstract

Abstract: : Purpose: To compare the validity of structural imaging (using optical coherence tomography) and functional imaging (using multifocal electroretinography) techniques in their ability in detection of cystoid macular edema (CME) in uveitic patients. Methods: 35 eyes of 18 consecutive patients with uveitis and suspected CME underwent volumetric OCT assessment, multifocal ERG and fluorescein angiography (FA). Criterion for macular thickening as measured by OCT was determined to be > 250 microns. The response density measurement of the first order kernel of the multifocal ERG within the central 5° region was determined and compared to age–appropriate normative data. The presence of CME was evalutated by the Gold Standard FA by an experimentally naive ophthalmologist. Results: When compared to FA determined presence of CME, the OCT showed a sensitivity of 45% (5/11) and a specificity of 66% (16/24). Multifocal electroretinography showed a much higher sensitivity of 90% (10/11) and a specificity of 60.8% (14/23) was obtained. Conclusions: OCT alone using a > 250 micron criteria was not specific for detection of CME in uveitic patients based on this study. The mERG has greater sensitivity in determining presence of CME, but with lower specificity. These findings suggest that a combination of functional and structural predictors would provide a better determination of the presence of CME in uveitic patients.

Keywords: electrophysiology: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • uveitis–clinical/animal model 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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