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S.G. Coupland, W.G. Hodge, B.C. Leonard, P.J. Kertes, A. Bhargava, W.R. Lamba; Correlates of Structural and Functional Imaging in the detection of uveitis–induced Cystoid Macular Edema . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2401.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the validity of structural imaging (using optical coherence tomography) and functional imaging (using multifocal electroretinography) techniques in their ability in detection of cystoid macular edema (CME) in uveitic patients. Methods: 35 eyes of 18 consecutive patients with uveitis and suspected CME underwent volumetric OCT assessment, multifocal ERG and fluorescein angiography (FA). Criterion for macular thickening as measured by OCT was determined to be > 250 microns. The response density measurement of the first order kernel of the multifocal ERG within the central 5° region was determined and compared to age–appropriate normative data. The presence of CME was evalutated by the Gold Standard FA by an experimentally naive ophthalmologist. Results: When compared to FA determined presence of CME, the OCT showed a sensitivity of 45% (5/11) and a specificity of 66% (16/24). Multifocal electroretinography showed a much higher sensitivity of 90% (10/11) and a specificity of 60.8% (14/23) was obtained. Conclusions: OCT alone using a > 250 micron criteria was not specific for detection of CME in uveitic patients based on this study. The mERG has greater sensitivity in determining presence of CME, but with lower specificity. These findings suggest that a combination of functional and structural predictors would provide a better determination of the presence of CME in uveitic patients.
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