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D.A. Nelson, S. Krupsky, M. Rosner, M. Belkin, A. Grinvald; Non–invasive characterization and quantification of blood flow in eyes with retinal vein occlusion . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2414.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To non–invasively detect and quantify retinal blood flow–rate deficiencies and abnormalities in patients diagnosed with retinal vein occlusion (RVO). Methods:A Retinal Functional Imager (RFI) was used to acquire sets of 8 sequential retinal images at 55 Hz, under red–free flash illumination. RBC motion can be directly visualized from such sets, and flow velocity quantified from this motion. User selected vessel segment widths and flow velocities were measured using the RFI's operator–supervised automatic analysis algorithms. Vessel segments were measured in study and unaffected eyes. In eyes with branch retinal vein occlusion (BRVO) vessels in the occluded area were evaluated. Segments were sub–categorized by diameter (0–25, 25–50, 50–75 µm). Results:Flow velocities were significantly lower for the affected vessel population (N= 6 eyes, 131 segments) than for size–matched vessels in control eyes (N= 3 eyes, 58 segments) (p < .001). The difference remained significant when RVO–affected vessels with stopping or retrograde blood flow were excluded from analysis (p < .01). Average ± Std. Dev. Flow Velocity (mm/sec) by Vessel Category
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