Retinal Arteriovenous Passage Times Derived From Fluorescein Angiography are Independent of AVP Times Derived From Indocyanine Green Angiography.

Abstract

Abstract: : Purpose: To assess whether a correlation exists between indocyanine green (ICG) and fluorescein angiography (FA) arteriovenous passage (AVP) times. Methods:All procedures were approved by an IRB, and informed consent was obtained. Examinations of eight healthy subjects were analyzed. Each subject had four consecutive visits two weeks apart. Both ICG and fluorescein angiography (FA) were performed using scanning laser ophthalmoscopy (SLO 101, Germany) and angiograms were obtained sequentially, ICG before fluorescein. Arteriovenous passage (AVP) times, the time elapsed between dye arrival in the artery and its corresponding vein, were calculated for FA and ICG from the videotaped angiograms by means of digital image analysis on a Mac G4 image processing workstation. FA and ICG AVP times were compared by linear regression. Results: There was no significant correlation between ICG and FA AVP times (p=0.3313, R²=0.045). Mean ICG AVP time was 1.417 seconds while mean fluorescein AVP time was 2.539 seconds. Conclusions: There is no correlation between AVP times with ICG and FA angiography. ICG data may not be a suitable substitute for FA data in the assessment of retinal hemodynamics.

Keywords: blood supply • retina • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)