May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Early retinal changes in a neonatal streptozotocin rat model of diabetes.
Author Affiliations & Notes
  • J.E. Mancini
    Ophthalmology,
    Facultad de Ciencias Biomedicas and Hospital Universitario Austral, Pilar – Buenos Aires, Argentina
  • J.C. Basabe
    Centro de Investigaciones Endocrinologicas, Hospital de Niños "R. Gutierrez", Buenos Aires, Argentina
  • J.O. Croxatto
    Ocular Pathology, Fundacion Oftalmologica Argentina "Jorge Malbran", Buenos Aires., Argentina
  • G. Kusminsky
    Oncohematology,
    Facultad de Ciencias Biomedicas and Hospital Universitario Austral, Pilar – Buenos Aires, Argentina
  • J.E. Gallo
    Ophthalmology,
    Facultad de Ciencias Biomedicas and Hospital Universitario Austral, Pilar – Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  J.E. Mancini, None; J.C. Basabe, None; J.O. Croxatto, None; G. Kusminsky, None; J.E. Gallo, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2476. doi:
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      J.E. Mancini, J.C. Basabe, J.O. Croxatto, G. Kusminsky, J.E. Gallo; Early retinal changes in a neonatal streptozotocin rat model of diabetes. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2476.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the presence of early retinal changes in a neonatal streptozotocin–injection rat model of diabetes. Methods: Wistar rats were injected with streptozotocin at the age of two days. Diabetic rats developed glicemia levels >200 mg/dl two days after. Four diabetic and four normal control animals were euthanized at 5 weeks. Wholemounts and cross sections of retinas were analyzed by light microscopy and immunofluorescence using GFAP antibody. Results: Wholemounts showed increased expresion of GFAP in retinal cells in diabetic rats compared with controls. Cross sections of the retina revealed that GFAP–positive cells had the morphology and spacial organization of Muller cells. Conclusions: The neonatal model of streptozotocin diabetic rat may be useful to evaluate the extent and mechanisms of early retinal damage.

Keywords: diabetes • diabetic retinopathy • retina 
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