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J. You, C.–H. Yang, J.–S. Huang, M.–S. Chen; Vitreous Levels of CX3C Chemokine, Fractalkine, in Vitreoretinal Diseases . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2496.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Chemokines play an important role in the pathogenesis of ocular inflammation and angiogenesis. Fractalkine, the CX3C chemokine, has been reported to be expressed in various ocular tissues and inflammatory mediators can modulate ocular fractalkine expression. To further understanding the role of fractalkine in ocular disorders, in this study, the vitreous levels of fractalkine were determined in various vitreoretinal diseases. Methods: Twenty–one subjects with proliferative diabetic retinopathy (PDR), six subjects with rhegmatogenous retinal detachment (RRD) and seven control subjects including 4 idiopathic epiretinal membrane and 3 idiopathic macular hole were enrolled. Vitreous samples were collected during pars plana vitrectomy. Fractalkine levels in vitreous were measured by enzyme–linked immunosorbent assay. Results: The vitreous levels of fractalkine both in the PDR group (3.42 + 2.03 ng/ml) and in the RRD group (3.93 + 2.76 ng/ml) were significantly higher than in control subjects (1.66 + 1.79 ng/ml) (Mann–Whitney U test, P = 0.032 and P= 0.002, respectively). No significant difference between PDR group and RD group was found (P= 0.57). Conclusions: In this study, elevated vitreous levels of fractalkine were noted in eyes with PDR and RRD. Fractalkine might play an important role in the pathogenesis of ocular angiogenetic diseases and proliferative vitreoretinopathy.
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