May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Pre and Post operative plasma expression of angiogenic markers in patients with proliferative diabetic retinopathy undergoing victrectomy
Author Affiliations & Notes
  • A.Y. Reginald
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
  • Y. Ghosh
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
  • S. Dhingra
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
  • S. Banergee
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
  • A. Tyagi
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
  • G.Y. H. Lip
    Ophthalmology, Birmingham Midland Eye Ctr, Birmingham, United Kingdom
    Cardiovascular Medicine, City Hospital, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships  A.Y. Reginald, None; Y. Ghosh, None; S. Dhingra, None; S. Banergee, None; A. Tyagi, None; G.Y.H. Lip, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2497. doi:
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      A.Y. Reginald, Y. Ghosh, S. Dhingra, S. Banergee, A. Tyagi, G.Y. H. Lip; Pre and Post operative plasma expression of angiogenic markers in patients with proliferative diabetic retinopathy undergoing victrectomy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2497.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To study pre and postoperative plasma levels of angiogenic factors [Vascular Endothelial Growth Factor (VEGF, an index of angiogenesis), soluble VEGF receptor (sFlt–1), Angiopoietin 1 & 2 (Ang–1, Ang–2) and soluble angiopoietin receptor TIE 2 (tie–2)] in patients with proliferative diabetic retinopathy undergoing elective victrectomy. Methods: Twenty three patients with proliferative diabetic retinopathy (18 male), with a mean age of 51 years (range 25 – 72) and no previous vitreo–retinal surgery, were studied. Blood samples were obtained on the day of surgery, and post–operatively, at 2 and 8 weeks. Baseline and post operative plasma levels of VEGF, sFLT– 1, Ang–1&2 and tie–2 were assayed using ELISA. 

P value by repeated measures ANOVA test. Conclusion:There was no significant variation in levels of VEGF, sFLT–1, Angiopoeitin 1 and 2 and TIE 2 in serum taken preoperatively and at postoperative follow up in diabetic patients undergoing elective vitrectomy for proliferative retinopathy. Vitrectomy does not appear to influence the expression of angiogenic markers in the peripheral plasma.

Keywords: diabetic retinopathy • immunohistochemistry • retinal neovascularization 
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