Laboratory analysis for the detection of oxidised LDL and high sensitivity C– reactive protein as possible pathogenic contributors in the aetiology of retinal vascular disorders

Abstract

Abstract: : Purpose:Oxidised LDL is believed to be a key trigger factor in the genesis of atherosclerosis . It has been postulated that it can activate inflammatory mediators such as C–reactive protein, IL6, TNF. These mediators have been demonstrated to have an atherogenic effect. Our purpose is to determine the role of oxidised LDL and High sensitivity C–reactive protein in the aetiology of retinal vascular disorders. Methods:Patients who presented with retinal vascular disorders to the ophthalmology department between August 2003 and September 2003 were enrolled into the study. There were7 patients and 2 controls.3 patients had Central retinal vein occlusion, 2 patients had Amaurosis Fugax,1 patient had Cilioretinal Artery Occlusion, and 1 patient had Cholesterol Embolus in Retinal Vasculature. None of the patients were taking aspirin or statins at the time of investigation. A value for High sensitivity C– reactive protein of greater than 3mg/l measured using a Beckman Turbidimetric assay was considered significant and oxidised LDL value greater than 59 U/L (median) using Mercodia OxidisedLDL ELISA assay was significant. Results:Oxidised LDL was raised in three patients, and at the upper end of normal in two of the seven patients although the LDL values were normal. No correlation was found between High sensitivity C–reactive protein and Oxidised LDL values. Conclusions:This study suggests that oxidised LDL may have a pathogenic role in retinal vascular disease. Further investigations are required to determine the significance of oxidised LDL in retinal vascular disease

Keywords: retina • ischemia