Effect of topical bunazosin hydorochloride on retinal and choroidal circulation in normal human eyes

Abstract

Abstract: : Purpose: To determine the short– and long–term effects of topical 0.01% bunazosin hydorochloride, a selectiveα1–blocker, on retinal and choroidal circulation in normal human eyes. Methods: Fifteen healthy volunteers received one drop of 0.01% bunazosin hydorochloride a twice–daily for 14 days in one eye and one drop of placebo in the fellow eye. Retinal arterial blood flow (RBF) was measured using a retinal Laser Doppler velocimetry (Canon, CLBF100). Pulsatile ocular blood flow (POBF) was measured using a Langham OBF tonometry system. Blood pressure, heart rate , intraocular pressure (IOP), retinal arterial diameter, retinal arterial blood velocity(RBV), RBF , POBF were measured before treatment, 90 minutes after the initial instillation, and after the last instillation on the 14th days. Results: Fourteen days later, the IOP decreased significantly and the RBF and RBV significantly increased by 17.6% ± 7.3% (p<0.05) and 18.2% ± 6.2% (p<0.05) in the bunazosin–treated eyes compared with the baseline. There were no significant changes in POBF in either eye. Conclusions: These results for the first time indicated that topical bunazosin hydorochloride may increase in RBF in normal eyes.

Keywords: drug toxicity/drug effects • retina • choroid