May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Dynamic autoregulation in the middle cerebral and ophthalmic artery
J. Kolodjaschna; F. Berisha; S. Lung; H. Schima; E. Polska; L. Schmetterer
Author Affiliations & Notes
  • J. Kolodjaschna
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • F. Berisha
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • S. Lung
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • H. Schima
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • E. Polska
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • L. Schmetterer
    of Clinical Pharmacology, University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  J. Kolodjaschna, None; F. Berisha, None; S. Lung, None; H. Schima, None; E. Polska, None; L. Schmetterer, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2620. doi:
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      J. Kolodjaschna, F. Berisha, S. Lung, H. Schima, E. Polska, L. Schmetterer; Dynamic autoregulation in the middle cerebral and ophthalmic artery . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2620.

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Abstract

Abstract: : Purpose: Blood flow autoregulation is defined as the ability of a tissue to maintain a relatively constant flow despite moderate alterations in perfusion pressure. Static and dynamic testing of autoregulation may assess some different aspects of the ocular response to changes in perfusion pressure. Dynamic autoregulation assesses the full time course of the autoregulatory process by analyzing beat–to–beat changes in both perfusion pressure and ocular blood flow parameters. We have adapted the thigh cuff technique to induce an ocular perfusion pressure step disturbance without drugs or changes in the concentration of vasoactive substances in the blood. Accordingly, we studied dynamic autoregulation using ultrasound technique in the middle cerebral and ophthalmic artery. Methods: 12 healthy nonsmoking male subjects were studied. Ultrasound parameters and arterial blood pressure (ABP) were recorded in each subjects before, during, and after a step drop in blood pressure. Continuous ABP recordings were made via a finger plethysmograph (Finapres, Ohmeda, Japan) with the subject's hand maintained at the same level as the heart. A thigh cuff technique was used to induce the drop in ABP. Large bilateral thigh cuffs were inflated and the thigh cuff pressure was approximately 20 mm Hg above peak systolic arterial pressure. The occlusion was maintained for 3 minutes and a drop in ABP was induced by rapid deflation of bilateral thigh cuffs. Only a decrease of ABP of more than 10 mm Hg was considered to be a sufficient stimulus for assessing autoregulation in the vessels. Results: The blood pressure decrease in blood pressures middle cerebral artery blood velocities and ophthalmic artery blood velocities was between 10 and 20% immediately after release of the thigh cuffs. The time course of return of blood velocities in the middle cerebral and the ophthalmic artery was, however, significantly different (p<0.001). Conclusions: The present data indicate that both middle cerebral and ophthalmic blood flow are autoregulated in response to changes in perfusion pressure. The mechanism, however, appears to be different in the middle cerebral and the ophthalmic artery.

Keywords: blood supply • choroid • imaging/image analysis: clinical 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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