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P. Stavrou, R. Sivaraj, M. Allie, P.A. Good; Electrophysiological, Heidelberg’s Retinal Tomography (HRT2) and Echographic assessment of patients with uveitis associated with sarcoidosis . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2704.
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Purpose: To investigate functional and structural, retinal and optic nerve changes in patients with uveitis associated with sarcoidosis using electrophysiology, Heidelberg’s retinal tomography (HRT2) and echography of the optic nerve head. Methods:Patients with uveitis associated with sarcoidosis underwent visual evoked potential (VEP), pattern and flash electroretinograms (ERG), HRT2 and echography of the optic nerve. Results: Thirteen patients were included. The male to female ratio was 4:9. Mean age was 47 years, range 15– 79 years. All but two patients had panuveitis and all but one patient had required immunosuppressive treatment for control of the uveitis. The mean visual acuity was 6/12 (range HM–6/5). Nine of the thirteen patients (70%) revealed flash and pattern ERG abnormalities. Five patients (38%) also revealed abnormalities of VEP, HRT2 and echography of the optic nerve (reduced optic nerve diameter and increased pial reflectivity). Conclusions: The results of this study show that a significant proportion (70%) of patients with uveitis associated with sarcoidosis had signs of retinal dysfunction as detected by flash and pattern ERG. In addition, 38% of patients had signs of optic neuropathy/ atrophy as detected by HRT2, VEP and echography of the optic nerve. All patients with optic neuropathy/ atrophy also had signs of retinal dysfunction. These findings suggest that the optic nerve involvement in this group of patients is more common than that identified clinically.
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