May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Extra–ocular inflammatory sites in patients with autoimmune uveitis and sarcoidosis.
Author Affiliations & Notes
  • S.G. Baarsma
    Ophthalmology, Eye Hospital Rotterdam, Rotterdam, The Netherlands
  • D.J. Kwekkeboom
    Nuclear medicin,
    Erasmus MC, Rotterdam, The Netherlands
  • R.W. A. M. Kuijpers
    Erasmus MC, Rotterdam, The Netherlands
  • P.L. A. Daele van
    Internal medicin,
    Erasmus MC, Rotterdam, The Netherlands
  • P.M. Hagen van
    Internal medicin,
    Erasmus MC, Rotterdam, The Netherlands
  • Footnotes
    Commercial Relationships  S.G. Baarsma, None; D.J. Kwekkeboom, None; R.W.A.M. Kuijpers, None; P.L.A. Daele van, None; P.M. Hagen van, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2708. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S.G. Baarsma, D.J. Kwekkeboom, R.W. A. M. Kuijpers, P.L. A. Daele van, P.M. Hagen van; Extra–ocular inflammatory sites in patients with autoimmune uveitis and sarcoidosis. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2708.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: Non–infectious uveitis is an inflammatory disease that is limited to the eye or can be associated with a systemic inflammatory disease. In the vast majority of patients with autoimmune uveitis no definite systemic (autoimmune) disease can be found. With radionuclide coupled octreotide we are able to detect specific inflammatory sites in patients with rheumatoid disease and granulomatous disease. This radiopharmaceutical binds to its receptors at inflammatory sites and results in the local accumulation of radioactivity. Visualization of ocular and extra–ocular sites can be achieved by scintigraphy and can be helpfull in the diagnosis of underlying disease. We looked at the efficacy of this diagnostic examination in uveitis patients. Methods: 45 consecutive patients with autoimmune uveitis and 16 patients with ocular sarcoidosis were injected intravenously with 10 microgram of [111In–DTPA–D–Phe1]octreotide (200–250 MBq). Planar images were obtained 24 hours after injection and a SPECT of the orbit was obtained 4 hours after injection. Results: In 26 out of 45 patients with "autoimmune uveitis" extra–ocular sites could be detected i.e. lung, nose, joints, heart, parotids and sini. In 15 out of 16 ocular sarcoidosis patients extra ocular sites were detected. Most frequently lung involvement was detected, whereas the X–ray of the lungs was positive in only 7 cases. Conclusions: Octreotide scintigraphy is a method to detect inflammatory sites. In patients with autoimmune uveitis this method suggests much more inflammatory sites than the eye. In ocular sarcoidosis this method can be used to detect systemic granulomatous inflammatory sites which can be helpful in the diagnosis of such patients.

Keywords: uveitis–clinical/animal model • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • autoimmune disease 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.