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F.V. L. Cabrita; Frequency of other autoimmune disorders in patients with Ocular Cicatricial Pemphigoid . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2712.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To report the frequency of other autoimmune disorders in patients with ocular cicatricial pemphigoid (OCP). Methods: Retrospective review of medical records of 47 patients with OCP (biopsy proven) at the Massachusetts Eye and Ear Infirmary between 1983 and 2003. The control group was age and sex–matched; it comprised of patients presenting to our service who were diagnosed with non–immune ocular disorders and who did not have any signs or symptoms suggestive of ocular autoimmune disease. The principal investigator (CSF) examined all patients. Results: 5 patients (10.6%) in the OCP patients group had other autoimmune disorders; 1 patient had systemic lupus erythematosus, 1 patient had eczema, 1 patient had IgA bullous disease. 2 patients had mixed connective tissue disease. The mean patient age in the study group was 73 years. In the control group also 5 patients (10.6%) had autoimmune disorders: 1 had psoriasis, 1 had colitis, 1 had rheumatoid arthritis, 1 had Hashimoto’s disease and 1 had diabetes mellitus type I. The mean patient age in the control group was 71 years and two months. The mean follow–up period was 4 years in the study group and 4 years and 10 months in the control group. Conclusion: In our study there is no difference in frequency of other autoimmune disorders between the control and OCP group. The most common autoimmune disease associated with OCP was mixed connective tissue disease (2 cases out of 5 patients with OCP and other autoimmune disorders).
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