May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Optical And Physical Model For Retinal Imaging In The Mouse.
Author Affiliations & Notes
  • R.A. Juarez
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
  • F. Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
  • R.W. Knighton
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
  • S.R. Uhlhorn
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
  • J.M. Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
  • Footnotes
    Commercial Relationships  R.A. Juarez, None; F. Manns, None; R.W. Knighton, None; S.R. Uhlhorn, None; J.M. Parel, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2788. doi:
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      R.A. Juarez, F. Manns, R.W. Knighton, S.R. Uhlhorn, J.M. Parel; Optical And Physical Model For Retinal Imaging In The Mouse. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2788.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To construct an optical and physical model of the mouse eye for the development of mouse retinal imaging systems. Methods: A reduced paraxial optical model of the mouse eye was developed using biometric and optical measurements published by Remtulla et al. (Vision Res.1985; 25,21–31), and Tejedor et al. (Ophthalmol Vis Sci. 2003;44:32–36). The reduced model was used to calculate entrance/exit pupil, retinal field of view, retinal image height, and develop a physical model that simulates the paraxial imaging system of the mouse. Results: The parameters of the reduced paraxial model are the following (all distances are given with respect to the anterior corneal surface): position of nodal point 1.548mm; position of entrance pupil 0.448mm; position of image focal plane 3.632mm; position of exit pupil –0.044mm. The entrance pupil magnification is 1.098 and the exit pupil magnification is 1.435 with a 2mm diameter mouse dilated pupil. The retinal full field of view is 88 degrees. The physical model consists of a 3mm diameter LaSFN9 plano convex lens with a refractive index of 1.850, and a focal length of 3mm, and a 3.83 mm long PMMA cylinder directly glued to the back surface of the lens. Conclusion: The study demonstrates the feasibility of building a physical model of the mouse eye using standard optical components. CR: None Support: We acknowledge the generosity of the Wollowick Family Foundation and Mrs. Patricia Wollowick for their support; the Florida Lions Eye Bank; Research to Prevent Blindness, NY, NY; The Henri and Flore Lesieur Foundation.

Keywords: optical properties • imaging/image analysis: non–clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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