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Y. Shildkrot, J.A. Young, C.M. Lee, I.P. Glavas; Fractal dimensions of retinal vascular patterns seen on intravenous fluorescein angiogram photographs of normal eyes and eyes with background diabetic retinopathy. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2800.
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© ARVO (1962-2015); The Authors (2016-present)
Objective: To compare fractal dimension of retinal vasculature in normal eyes and in eyes with background diabetic retinopathy (BDR) as seen on intravenous fluorescein angiography (IVFA) photographs. Methods: IVFA images were digitized using a professional high–resolution transparency scanner and analyzed using commercial fractal analysis software. Eyes with history of laser treatment or unrelated pathology were excluded from the analyses. Results:21 eyes of 13 patients with BDR and 5 eyes of 5 patients with no retinal pathology were enrolled. There was a significant difference in mean fractal dimension between the two groups: eyes with BDR FD = 1.695 ± 0.059, normal eyes FD = 1.520 ± 0.053 (p = 0.00000341). Conclusion:Fractal analyses of digitized IVFA photographs revealed significant difference between normal eyes and eyes with background diabetic retinopathy. Therefore, determination of fractal dimension appears to be a promising tool for automated IVFA processing. Further research in image standardization is needed to allow wider use of this methodology.
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