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F. Luengo, J.I. Ferro, S. Gatto, S. Arias, J.O. Croxatto, J.E. Gallo; Autologous platelet rich plasma (PRP) as a biological adhesive in lamellar keratoplasty . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2927.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To demonstrate the usefulness of autologous platelet rich plasma (PRP) as a biological adhesive in lamellar keratoplasty (LK) Methods: An autologous six millimeters lamellar graft was performed in 12 albino rabbits. Autologous PRP was applied on the stromal surface and the corneal botton was replaced. Topical tobramicine and dexametasone were postoperatively used. Rabbits were euthanised for histological evaluation at 48 hs, 1, 4, and 12 weeks after surgery. Results: Clinically, all the rabbits showed successful graft attachment and clear cornea at 12 weeks. Histopathologic examination showed mild inflammation in the initial stages and a well adhered lamellar graft with mild keratocyte activity at 12 weeks. Conclusions: Autologous platelet rich plasma may be a useful tool in lamellar keratoplasty and flap adherence after LASIK.
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