May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Autologous platelet rich plasma (PRP) as a biological adhesive in lamellar keratoplasty
F. Luengo; J.I. Ferro; S. Gatto; S. Arias; J.O. Croxatto; J.E. Gallo
Author Affiliations & Notes
  • F. Luengo
    Department of Ophthalmology,
    Hospital Universitario Austral and Facultad de Ciencias Biomedicas, Pilar, Buenos Aires, Argentina
  • J.I. Ferro
    Medical Transfusional Service,
    Hospital Universitario Austral and Facultad de Ciencias Biomedicas, Pilar, Buenos Aires, Argentina
  • S. Gatto
    Medical Transfusional Service,
    Hospital Universitario Austral and Facultad de Ciencias Biomedicas, Pilar, Buenos Aires, Argentina
  • S. Arias
    Medical Transfusional Service,
    Hospital Universitario Austral and Facultad de Ciencias Biomedicas, Pilar, Buenos Aires, Argentina
  • J.O. Croxatto
    Ocular Pathology, Fundacion Oftalmologica Argentina "Jorge Malbran", Buenos Aires, Argentina
  • J.E. Gallo
    Department of Ophthalmology,
    Hospital Universitario Austral and Facultad de Ciencias Biomedicas, Pilar, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  F. Luengo, None; J.I. Ferro, None; S. Gatto, None; S. Arias, None; J.O. Croxatto, None; J.E. Gallo, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2927. doi:
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      F. Luengo, J.I. Ferro, S. Gatto, S. Arias, J.O. Croxatto, J.E. Gallo; Autologous platelet rich plasma (PRP) as a biological adhesive in lamellar keratoplasty . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2927.

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Abstract

Abstract: : Purpose: To demonstrate the usefulness of autologous platelet rich plasma (PRP) as a biological adhesive in lamellar keratoplasty (LK) Methods: An autologous six millimeters lamellar graft was performed in 12 albino rabbits. Autologous PRP was applied on the stromal surface and the corneal botton was replaced. Topical tobramicine and dexametasone were postoperatively used. Rabbits were euthanised for histological evaluation at 48 hs, 1, 4, and 12 weeks after surgery. Results: Clinically, all the rabbits showed successful graft attachment and clear cornea at 12 weeks. Histopathologic examination showed mild inflammation in the initial stages and a well adhered lamellar graft with mild keratocyte activity at 12 weeks. Conclusions: Autologous platelet rich plasma may be a useful tool in lamellar keratoplasty and flap adherence after LASIK.

Keywords: cornea: stroma and keratocytes • cornea: basic science • transplantation 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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