May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Autofluorescence patterns in central serous retinopathy
Author Affiliations & Notes
  • A. Walter
    Dept Ophthalmology, University Regensburg, Regensburg, Germany
  • B. Gabler
    Dept Ophthalmology, University Regensburg, Regensburg, Germany
  • H. Sachs
    Dept Ophthalmology, University Regensburg, Regensburg, Germany
  • J. Roider
    Dept Ophthalmology, University Kiel, Kiel, Germany
  • C. Framme
    Dept Ophthalmology, University Regensburg, Regensburg, Germany
  • V.–P. Gabel
    Dept Ophthalmology, University Regensburg, Regensburg, Germany
  • Footnotes
    Commercial Relationships  A. Walter, None; B. Gabler, None; H. Sachs, None; J. Roider, None; C. Framme, None; V. Gabel, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2963. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      A. Walter, B. Gabler, H. Sachs, J. Roider, C. Framme, V.–P. Gabel; Autofluorescence patterns in central serous retinopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2963.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:Central serous retinopathy (CSR) affects mostly young and middle–aged adults. Typically a serous retinal detachment occurs with a focal leakage point in fluorescein angiography. Fundus autofluorescence (AF) is related to the lipofuscin within the retinal pigment epithelium (RPE). Since CSR is thought to be associated with RPE disorders, AF measurements might be able to detect distinct changes within the RPE level. Purpose of the study was the comparison of AF patterns in acute and chronic–recurrent CSR and to evaluate its potential value as a non–invasive monitoring tool. Methods: From 85 patients diagnosed with CSR (mean age 43 years) AF images were retrospectively evaluated and compared with the angiographic, ophthalmoscopic and OCT findings. Fluorescein angiography and AF measurements were performed using the Heidelberg Retina Angiograph (Heidelberg, Germany). AF was excited by a wavelength of 488 nm and detected above 500 nm. Results:Acute CSR as determined by acute decrease of visual acuity within the last 6 weeks, focal point leakage and neurosensory retinal detachment was diagnosed in 39 patients. In 36 of those patients (92%) either a significant decreased AF at the leakage point (72%) and / or decreased AF in the area of neurosensory detachment (77%) was observed. In 20 patients OCT measurements were available showing neurosensory detachment (n=19) and RPE detachment (n=3). Regarding chronic–recurrent CSR as determined by a decrease of visual acuity for longer than six weeks and mottled appearance of angiographic fluorescence, abnormalities in AF were observed in 44/46 patients (96%). In those patients at the leakage point itself decreased or mottled AF was observed (76%), whereas significantly increased AF was seen in the area of presumed former retinal detachment (83%). OCT was available up to now in 9 patients with chronic CSR, showing no neurosensory elevation (n=3) or slight residual elevation (n=6) in the area of increased AF. Conclusions:In acute CSR AF is decreased presumably due to a blockage from edema whereas in chronic forms irregular and increased AF is observed, which might be regarded to reactive RPE changes secondary to RPE defects and the former neurosensory detachment. Thus AF seems to be an interesting non–invasive tool to monitor RPE changes in CSR and to use it for differential diagnosis.

Keywords: retinal pigment epithelium • retina • retinal detachment 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×