Purchase this article with an account.
J.D. McCluskey, H. Wafapoor, C.J. Chen, L.L. Chen, M.L. Palmer, W. May; The Effects of Intraocular Triamcinolone on Persistent Diabetic Macular Edema as Measured by Optical Coherence Tomography (OCT) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2974.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose:To examine the effects of Intraocular Triamcinolone (ITC) on macular thickness as measured by OCT in Persistent Diabetic Macular Edema (PDME). Methods: A retrospective chart review of patients that had PDME following grid or focal laser was performed from November 2002 until January 2004. All patients that were treated with 4 mg ITC injection were included in the study. Prior to ITC a complete eye exam including fluorescein angiography and OCT was performed. This exam was repeated at 1, 3, and 6 months. The following demographic information was also collected on each patient: age, sex, race, body mass index, blood pressure, HgbA1C, tobacco use, lipid profile, statin medications, and insulin use. Results: A total of 21 patients (21 eyes) were included in the study. Age ranged from 58–80 years old. Race included 14 caucasian patients and 7 African American patients. Prior to ITC injection, the foveal thickness (FT) was 439 + 161 µ , inner macular thickness (IMT) ranged from 373 + 118 µ to 416 + 69 µ, outer macular thickness (OMT) ranged from 281 + 51µ to 321 + 63µ . Visual acuity before ITC injection ranged from 20/25 to count finger. The FT at 1, 3, 6 months following ITC injection was 241 + 50 µ, 262 + 92 µ, and 346 + 118 µ. There was a 40–45% reduction in FT at 1 and 3 months, the reduction was 20% at 6 months. This reduction pattern was also seen for IMT and OMT. The visual acuity of 5 patients improved 2 or more Snellen lines. Vision remained stable in 15 patients and one patient had a decrease in vision. The most common complication was increased intraocular pressure. Conclusions: ITC may be considered as a treatment for PDME. A significant decrease in macular thickness by OCT was measured at 1 and 3 months follow up. However, the effectiveness of intraocular triamcinolone may decrease at six months. Visual acuity improved or remained stable in 20 out of 21 patients.
This PDF is available to Subscribers Only