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M.K. Webster, B.A. Blodi, J.A. Elledge, K.G. Csaky, CPDT1 Study Research Group; COMPARISON OF OCT AND FLUORESCEIN ANGIOGRAPHIC FEATURES OF CHOROIDAL NEOVASCULARIZATION DUE TO AGE–RELATED MACULAR DEGENERATION . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3061.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To compare optical coherence tomography (OCT) findings in eyes with choroidal neovascularization due to age–related macular degeneration (AMD) to the corresponding CNV type as determined by fluorescein angiography (FA). Methods: We independently graded baseline fluorescein angiograms and optical coherence tomography (OCT) from fifty–three patients enrolled in the CPDT1 (Celebrex and Photodynamic Therapy) Study. CNV were categorized from fluorescein angiograms based on the Macular Photocoagulation Study (MPS) criteria for classic and occult CNV. OCT scans were graded for the following 5 abnormalities of the retinal pigment epithelium (RPE): thickening, fusiform thickening (suggestive of classic CNV), disruption, sharp elevation (suggestive of a serous pigment epithelial detachment), and enhanced reflectivity below the RPE band (suggestive of occult CNV). Results:Disruption of the RPE layer was evident in 100% of the OCTs evaluated and thickening of the RPE layer was evident in 96%. Fusiform thickening was noted in 44% (4/9) of predominantly classic lesions, 35% (7/20) of minimally classic lesions, and 8% (2/24) of occult lesions. Enhanced reflectivity below the RPE band was noted in 22% (2/9) of predominantly classic lesions, 35% (7/20) of minimally classic lesions and 33% (8/24) of occult lesions. Conclusions:We found it difficult to classify CNV type using OCT features alone. However, OCT does provide additional information about the morphology of the retinal pigment epithelium.
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