May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Immunohistochemistry findings in intraretinal proliferative vitreoretinopathy (iPVR)
J. Pastor; M. de la Fuente; R. Sanabria; E. Rodríguez de la Rúa; J. García–Arumí; M. Garcia; M. Mendez; N. Fernandez; M. Saornil
Author Affiliations & Notes
  • J. Pastor
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • M. de la Fuente
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • R. Sanabria
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • E. Rodríguez de la Rúa
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • J. García–Arumí
    Servicio de Oftalmología, Hospital Vall de Hebron, Barcelona, Spain
  • M. Garcia
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • M. Mendez
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • N. Fernandez
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • M. Saornil
    Instituto de Oftalmobiologia Aplicada–IOBA, University of Valladolid, Valladolid, Spain
  • Footnotes
    Commercial Relationships  J. Pastor, None; M. de la Fuente, None; R. Sanabria, None; E. Rodríguez de la Rúa, None; J. García–Arumí, None; M. Garcia, None; M. Mendez, None; N. Fernandez, None; M. Saornil, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3195. doi:
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      J. Pastor, M. de la Fuente, R. Sanabria, E. Rodríguez de la Rúa, J. García–Arumí, M. Garcia, M. Mendez, N. Fernandez, M. Saornil; Immunohistochemistry findings in intraretinal proliferative vitreoretinopathy (iPVR) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3195.

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Abstract

Abstract: : Purpose: We have recently published the existence of retinal shortening (intraretinal PVR), in cases of PVR, besides the presence of preretinal and/or subretinal membranes. We now seek to analyze the retina specimens obtained in those cases that required a retinectomy to reattach the retina. Methods: Samples from 13 patients with postoperative iPVR, developed within the 2 first months after primary surgery for retinal detachment (RD), have been analyzed for the presence of: Vimentin, Cytokeratins (CKs), Glial Fibrillary Acidic Protein (GFAP) and CD68 by immunohistochemistry. A normal posterior pole from the eye–bank and 2 globes removed after complicated RD surgery, with PVR, were used as controls Results: Positive staining for Vimentin and GFAP was shown in 13/13 samples in the retinal tissue; remainings of epiretinal membranes attached to the retina were present in 10/13 cases, all negative for GFAP; 4/13 retinal tissues showed pigmented cells positive for CKs; 3/10 epiretinal membranes were also positive for CKs; 11/13 retinal tissues, 6/10 epiretinal membranes and 2 vitreous remains showed CD68 positive cells. Conclusions: Retinal shortening due to iPVR is caused by a gliotic response, a mechanism different from that implicated in epiretinal membranes. The presence of macrophages in retinal tissues indicates a possible important role of these cells in the pathogenesis of iPVR. Nevertheless, further studies with larger samples are necessary

Keywords: retinal detachment • clinical (human) or epidemiologic studies: natural history • immunohistochemistry 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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