May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Pointwise relationship between OCT nerve fiber layer thickness and visual field threshold level
G. Wollstein; H. Ishikawa; S. Beaton; D.M. Stein; M. Aoyama; J.G. Fujimoto; J.S. Schuman
Author Affiliations & Notes
  • G. Wollstein
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • H. Ishikawa
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • S. Beaton
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • D.M. Stein
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • M. Aoyama
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • J.G. Fujimoto
    Dept. of Electrical Engineering and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • J.S. Schuman
    Dept. of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Footnotes
    Commercial Relationships  G. Wollstein, None; H. Ishikawa, None; S. Beaton, None; D.M. Stein, None; M. Aoyama, None; J.G. Fujimoto, Carl Zeiss Meditec Inc. C, P; J.S. Schuman, Carl Zeiss Meditec Inc. C, P.
  • Footnotes
    Support  National Eye Institute (R01–EY13178, RO1–EY11289 and P30–EY13078) and Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3329. doi:
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      G. Wollstein, H. Ishikawa, S. Beaton, D.M. Stein, M. Aoyama, J.G. Fujimoto, J.S. Schuman; Pointwise relationship between OCT nerve fiber layer thickness and visual field threshold level . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3329.

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Abstract

Abstract: : Purpose:To determine the relationship between segmental nerve fiber layer (NFL) thickness as measured by optical coherence tomography (OCT; Stratus OCT, Carl Zeiss Meditec, Dublin, CA) and visual field (VF) threshold level. Methods:Thirty seven normal subjects and 37 glaucoma patients were recruited for this study. All participants had reliable and reproducible SITA standard 24–2 Humphrey perimetry and good quality OCT scanning of the peripapillary region acquired within six months (median interval: 0 days). VF threshold levels were recorded as decibels and as 1/Lambart (dB = 10*log 1/Lambart). OCT NFL thickness was recorded for 12 clock hours and four quadrants. Segmental OCT NFL thickness and corresponding VF threshold levels were defined based on Garway–Heath et al.'s map (Ophthalmol 2000; 1809–15). The relationship between NFL and VF measurements was defined by linear regression and polynomial fit models. Results:The mean age of the normal subjects and the glaucoma patients was 55.2 ± 8.1 and 68.1 ± 11.7 years, respectively. The VF mean deviation was 0.07 ± 1.20 dB for the normal group and –6.81 ± 4.96 dB for the glaucoma group. A polynomial model provided the best fit between OCT NFL measurements and segmental VF threshold levels both for dB and for 1/Lambart units. The difference between the linear and the polynomial fit was significant (p < 0.05) in four temporal clock hours and two quadrants. Except for four temporal clock hours (7, 9 – 11) and the temporal quadrant, the dB units had a better fit with NFL thickness than the 1/Lambart. All correlations were statistically significant at a level of p < 0.05. The best fit was in the superior and inferior poles (R2 = 0.58 at 7 o’clock and 0.41 at 11 o’clock). Conclusions: The correlation between OCT NFL thickness and VF threshold level ranged from weak to moderate for the various segments. A polynomial model provided a better fit than linear regression and dB units better than 1/Lambart.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • visual fields 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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