May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Detectability of early glaucomatous change using scanning laser polarimetry with variable corneal compensator
Author Affiliations & Notes
  • T. Agawa
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
  • M. Osako
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
  • K. Yamada
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
  • M. Miura
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
  • K. Tachibana
    Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
  • M. Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
  • Footnotes
    Commercial Relationships  T. Agawa, None; M. Osako, None; K. Yamada, None; M. Miura, None; K. Tachibana, None; M. Usui, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3353. doi:
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    • Get Citation

      T. Agawa, M. Osako, K. Yamada, M. Miura, K. Tachibana, M. Usui; Detectability of early glaucomatous change using scanning laser polarimetry with variable corneal compensator . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3353.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: We evaluate the detectability of early glaucoma using scanning laser polarimetry with variable corneal compensator (GDx VCC, Laser diagnostic Technologies) by comparing with the results of scanning laser polarimetry with fixed corneal compensator (GDx FCC). Methods:Thirty–two eyes of 32 patients (mean age, 61.2 years) with early glaucomatous visual field change were studied. The classification of glaucoma was primary open–angle glaucoma in 15 eyes and normal–tension glaucoma in 17 eyes. The mean deviation (MD) of Program 24–2 of the Humphrey Field Analyzer (HFA) were greater than – 5.0 dB in all eyes. Each eye was tested using GDx VCC and GDx FCC. Evaluation was performed using GDx parameters such as TSNIT Average (TA), Superior Average (SA), Inferior Average (IA), TSNIT Standard Deviation (TSD), and Nerve Fiber Indicator (NFI). A case with any parameter below the 95% confidence interval was defined as abnormal (for NFI, greater than 50 in GDx VCC or greater than 60 in GDx FCC was abnormal). Comparison of detectability was done by Wilcoxon sighed rank test. Furthermore, correlation between each parameter and MD of the HFA was analyzed. Results:GDx VCC showed significantly better sensitivity than GDx FCC in TA, SA, IA (p<.02), whereas no significant difference was found in TSD and NFI. When defining a case with any parameter outside the normal limit (p<.05) as abnormal, the sensitivity was 81.3% for GDx VCC and 53.1% for GDx FCC, with a significant difference (p=.02). Although no parameter of GDx FCC correlated significantly with MD, TA (r=.38, p<.0001), SA (r=.42, p<.02) and NFI (r=.46, p<.001) of GDx VCC showed significant correlation with MD. Conclusions: GDx VCC detected early glaucoma better than GDx FCC, and shows good correlation with visual field.

Keywords: imaging/image analysis: clinical • nerve fiber layer • visual fields 
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