May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Comparison of Disease Progression in Glaucoma using the HRT and Expert Optic Nerve Head Assessment of Stereophotos
D. Kourkoutas; Y.M. Buys; J. Flanagan; W. Hatch; E. Eskander; G.E. Trope
Author Affiliations & Notes
  • D. Kourkoutas
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • Y.M. Buys
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • J. Flanagan
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • W. Hatch
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • E. Eskander
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • G.E. Trope
    Department of Ophthalmology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  D. Kourkoutas, None; Y.M. Buys, None; J. Flanagan, None; W. Hatch, None; E. Eskander, None; G.E. Trope, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3354. doi:
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      D. Kourkoutas, Y.M. Buys, J. Flanagan, W. Hatch, E. Eskander, G.E. Trope; Comparison of Disease Progression in Glaucoma using the HRT and Expert Optic Nerve Head Assessment of Stereophotos . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3354.

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Abstract

Abstract: : Purpose: To compare disease progression in glaucoma using Heidelberg Retinal Tomography (HRT) and expert optic nerve head (ONH) assessments of stereophotos Methods:One eye of 56 subjects with glaucomatous optic neuropathy was reviewed using HRT examinations and ONH stereophotos. The ONH stereophotos were assessed twice for glaucomatous progression by two expert observers (GT & YB). The experts were considered to be ‘in agreement’ if the results were the same in at least 3 out of 4 assessments. Progression on the HRT was defined as a cluster of 20 or more superpixels, showing topographic change outside the normal limits (excluding vessels), on 3 consecutive visits. The expert observers’ assessments were used as the ‘reference standard’ to determine the sensitivity and specificity of the HRT analysis Results: 

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The expert observers were in agreement in 51 subjects (91%). Consensus agreement was necessary in the remaining 5 subjects. Concordance between the HRT and stereophoto assessments was obtained in 39 patients (70%). Using the stereophoto assessments as the "reference standard", HRT specificity was 75% and sensitivity was 50%. The positive predictive value of the HRT was 35%, while the negative predictive value was 85%. Using HRT as the "reference standard", stereophoto assessment specificity was 85% and sensitivity was 35%. The positive predictive value of the stereophoto assessments was 50%, and the negative predictive value was 75%. Conclusions:The agreement between progression using HRT and progression with stereophoto assessment was weak.

Keywords: imaging/image analysis: clinical • optic disc 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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