Abstract
Abstract: :
Purpose: To report efficacy of photodynamic therapy (PDT) in treatment of 9 cases of juxtafoveal circumscribed choroidal hemangioma. Methods: Data on 9 patients (6 primary, 2 failed TTT, and 1 failed radiotherapy) treated with verteporfin, 6mg/m2 given as IV infusion over 10 minutes. Diode laser (692 nm) with an intensity of 600 mW/cm2 for 83 seconds (50mJ/cm2) was applied 5 minutes after completion of infusion. Overlapping multiple spots (2500 micron) were applied to cover the entire surface of the tumor. The median pretreatment tumor size was 7 mm (base) x 2.5 (thickness) mm. Periodic follow–up with ophthalmoscopy, ultrasonography, and angiographic studies was performed. Results: All cases (100%) showed regression of the tumor with resolution of subretinal fluid, flattening of tumor, and absence of choroidal vasculature on ICG. The visual acuity either improved or remained stable in 7 cases. RPE atrophy was noted in 2 cases with associated reduction of vision. The overlying retinal vessels remained unaffected. There were no systemic complications. Conclusions: PDT is an effective treatment for juxtafoveal circumscribed choroidal hemangioma. There is risk of visual loss due to RPE atrophy.
Keywords: tumors • oncology • choroid