Abstract
Abstract: :
Purpose: Eyelid hidrocystomas are benign neoplastic proliferations arising in the apocrine glands of Moll or in the eccrine glands present at the eyelid margin and in the dermis. We used imunohistochemistry to investigate the derivation of a consecutive series of hidrocystomas. Methods: Utilizing immunohistochemistry, 25 eyelid hidrocystomas were studied. Apocrine differentiation was assessed using BRST–2, CD15, MUC–1 antibodies, and eccrine differentiation was assessed using S–100 antibodies. Immunohistochemical reactivity was graded as positive or negative. Results: Of the 25 eyelid lesions evaluated, 17 were positive for S–100 (nuclear and/or cytoplasmic staining), and another 5 were equivocally positive. Three were negative for S–100 but positive for BRST–2. Of these three, only one showed CD15 and MUC–1 positivity. In the remaining 22 cases, there was positive or equivocal MUC–1 and/or CD15 staining in 9 cases, including some S–100 positive cysts. Conclusions: The majority of eyelid hidrocystoma are of eccrine origin. BRST2 is a reliable marker in apocrine hidrocystomas, which are less common. MUC–1 and CD15 staining does not add to the differentiation of these lesions.
Keywords: immunohistochemistry • eyelid • tumors