Abstract
Abstract: :
Purpose: Anterior subcapsular cataract shows an opacity beneath the anterior capsule and a transdifferentiation of the lens epithelial cells has been regarded as a main pathogenesis. This change is different from a change of lens fiber proteins in other type cataracts. In this study, we examined the prevalence in cataract patients–based study and risk factors for anterior subcapsular cataract. Methods: 13,029 eyes who had undergone cataract surgery in the Kangnam Mary’s Hospital in Korea from March 1995 to December 2001 was reviewed in a retrospective case–control study. And we evaluated the risk factors for anterior subcapsular cataract patients and compared them with 552 non–cataract persons. We used the odds ratio(OR) and their 95% confidence intervals (CI) through multiple logistic regression to evaluate relations of ocular trauma, intraocular disease, family history, birth place, residence, occupation, sun–light exposure, drinking habit, smoking habit, systemic disease, long–term used drugs, glasses wearing history and feminine parity with anterior subcapsular cataract. Results: Cataract patients based prevalence of anterior subcapsular cataract was 4.82% (628 eyes) and male of 82.0% and female of 18.0%. Average age of anterior subcapsular cataract patients was 51.9 years and under 50 years was 45.4% and 50∼59 years was 28.9%. Among the risk factors ocular trauma (OR 8.75, 95% CI 2.83 to 27.08), intraocular disease (OR 3.47, 95% CI 1.19 to 10.15) in male and diabetes (OR 3.57, 95% CI 1.14 to 11.15) in female were significantly associated with anterior subcapsular cataract. Conclusions: Cataract patients based prevalence of anterior subcapsular cataract was about 5%. Anterior subcapsular cataract had a high prevalence in persons under 60 years old (74.3%) and man (82.0%). Ocular trauma seems to be the highest risk factor for a cataract patients based prevalence of anterior subcapsular cataract.
Keywords: cataract • clinical (human) or epidemiologic studies: prevalence/incidence • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology