May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Risk Factors for the Progression of Lens Opacities in the Age–Related Eye Disease Study (AREDS)
Author Affiliations & Notes
  • T.E. Clemons
    The EMMES Corporation, Rockville, MD
  • B.E. K. Klein
    Dept of Ophthalmology & Visual Sciences, University of Wisconsin, Madison, WI
  • R.D. Sperduto
    National Eye Institute, Bethesda, MD
  • AREDS Research Group
    The EMMES Corporation, Rockville, MD
  • Footnotes
    Commercial Relationships  T.E. Clemons, None; B.E.K. Klein, None; R.D. Sperduto, None.
  • Footnotes
    Support  NIH Contract NO1EY02127
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3751. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T.E. Clemons, B.E. K. Klein, R.D. Sperduto, AREDS Research Group; Risk Factors for the Progression of Lens Opacities in the Age–Related Eye Disease Study (AREDS) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3751.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:To describe the association of risk factors with the progression of type–specific lens opacities in AREDS. Methods: Progression of nuclear opacity (a 1.5–unit increase on a severity scale from 0.9 – 6.1), cortical opacity (10% absolute increase in area of opacity within a standard central 5–mm circle) and PSC opacity (5% absolute increase in the area of opacity within a standard central 5–mm circle) was assessed in AREDS from lens photographs taken at baseline and at annual visits. Average follow–up time was 6.3 years. Baseline risk factors considered included demographic, medical history, use of medications, and ocular factors. Staged model–building with repeated–measures logistic regression was used to identify and assess significant baseline risk factors separately for progression of nuclear opacity among 4,331 participants with follow–up Topcon slit–lamp photographs, and for progression of cortical and PSC opacity among 4,329 participants with follow–up Neitz retroillumination photographs. Results:In multivariable models controlling for age and gender, history of multivitamin use was associated with decreased risk of the progression of nuclear opacity (OR 0.83, 95% CI 0.73, 0.95). For cortical opacity, higher Eeducational status (college grad. vs. high school grad. or less, OR 0.72, 95% CI 0.57, 0.91), and white race (white vs other, OR 0.39, 95% CI 0.27, 0.58) were associated with decreased risk of progression, whereas beta–blocker use (OR 1.48, 95% CI 1.01, 2.16), and hyperopic refractive error (hyperopic vs. myopic, OR 1.43, 95% CI 1.02 – 2.02) were associated with increased risk ofthe progression of cortical opacity. History of angina (OR 1.42, 95% CI 1.04, 1.94) and diabetes (OR 1.63, 1.18, 2.25) were associated with the increased risk of progression of PSC opacity. Conclusion:Data from this large longitudinal study showed several environmental nd systemic exposures demographic, medical history, medication use, and ocular factors that were associated with the risk of progression of type–specific lens opacities.

Keywords: cataract • clinical (human) or epidemiologic studies: risk factor assessment 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×