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O. Abdiu, T. Blalock, G. Schultz, G. Grotendorst, G. van Setten; Possible Involvement of of Connective Tissue Growth Factor (CTGF) in Subepithelial Fibrosis of Bullous Keratopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3843.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Subepithelial fibrosis (SF) is known to occur in various corneal diseases. The underlaying pathophysiology is yet unclarified but accumulation of fibrotic substances and extracellular matrx components appear to play a major role. Intention of the present study was to illuminate the possible involvement and contribution of connective tissue growth factor (CTGF) in SF. Methods: Immunohistological staining with specific antibodies against human CTGF. Sections from twenty surgical specimens of corneal buttons received after corneal transplantation. Results: Patchy accumulation of specific staining for CTGF was found in subepithelial localization. No specific stianing could be shown for the deeper parts of the corneal stroma. Control sections were negative. Conclusions: We conclude that a contribution of CTGF in the process of subepithelial fibrosis in cases of bullous keratopathy is very likely. The exact mechanism neads to be clarified. Our current study extend now to investigate the presence of CTGF in other pathologies known to lead to corneal SF such as refractive surgery. The demonstrated presence and suggested involvement of CTGF in the pathophysiology of SF could be a first step in the possible prevention of SF with new therapeutic agents.
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