May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Possible Involvement of of Connective Tissue Growth Factor (CTGF) in Subepithelial Fibrosis of Bullous Keratopathy
Author Affiliations & Notes
  • O. Abdiu
    Dept Ophthalmology, St Eriks Eye Hosp, Stockholm, Sweden
  • T. Blalock
    Inst of Wound Reserach,Dep Ob /Gyn,
    University of Florida, Gainesville, FL
  • G. Schultz
    Inst of Wound Research / Dept Ob / Gyn,
    University of Florida, Gainesville, FL
  • G. Grotendorst
    Dept of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, FL
  • G. van Setten
    Dept Ophthalmology, St Eriks Eye Hosp, Stockholm, Sweden
  • Footnotes
    Commercial Relationships  O. Abdiu, None; T. Blalock, None; G. Schultz, None; G. Grotendorst, None; G. van Setten, None.
  • Footnotes
    Support  EY05587, GM037223, GM03723, Synfrämjandets Forskningsfond, Sweden
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3843. doi:
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    • Get Citation

      O. Abdiu, T. Blalock, G. Schultz, G. Grotendorst, G. van Setten; Possible Involvement of of Connective Tissue Growth Factor (CTGF) in Subepithelial Fibrosis of Bullous Keratopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3843.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Subepithelial fibrosis (SF) is known to occur in various corneal diseases. The underlaying pathophysiology is yet unclarified but accumulation of fibrotic substances and extracellular matrx components appear to play a major role. Intention of the present study was to illuminate the possible involvement and contribution of connective tissue growth factor (CTGF) in SF. Methods: Immunohistological staining with specific antibodies against human CTGF. Sections from twenty surgical specimens of corneal buttons received after corneal transplantation. Results: Patchy accumulation of specific staining for CTGF was found in subepithelial localization. No specific stianing could be shown for the deeper parts of the corneal stroma. Control sections were negative. Conclusions: We conclude that a contribution of CTGF in the process of subepithelial fibrosis in cases of bullous keratopathy is very likely. The exact mechanism neads to be clarified. Our current study extend now to investigate the presence of CTGF in other pathologies known to lead to corneal SF such as refractive surgery. The demonstrated presence and suggested involvement of CTGF in the pathophysiology of SF could be a first step in the possible prevention of SF with new therapeutic agents.

Keywords: cornea: clinical science • pathology: human • growth factors/growth factor receptors 
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