Abstract
Abstract: :
Purpose:Conjunctival and corneal intraepithelial neoplasia (CIN) is one of the most common conjunctival malignancy. Basic management of CIN is surgical excision, and many adjunctive therapies have been used for the inhibition of recurrence, including radiation, cryotherapy, mitomycin–C, and 5–fluorouracil. These adjunctive therapies, however, are not suitable for the reconstruction of ocular surface after excision, because of cytotoxic nature of these treatments. Recently the effectiveness of topical interferon α–2b (INFα2b) against CIN has been reported. We evaluated the suitability of topical INFα2b and ocular reconstruction surgeries. Methods:Four patients were studied prospectively. After wide excision of tumor, we performed limbal allograft transplantation for two patients, and amniotic membrane transplantation for other two patients. After these operations, topical recombinant INFα2b was administered with 1 million IU / ml four times a day for one month. And they were followed clinically and photographically for evidence of tumor resolution and recurrences. All excised lesions were histologically proved to be carcinoma in situ in all cases. Results:All patients had complete resolution of the tumor. The mean follow–up time was 16.5 M (range 2 – 29M), and the recurrence of the tumor was not found. In one case, residual tumor had disappeared after 5 days’ instillation of interferon. Epithelial defect was observed in one case, however the defect was healed with no discontinuation of interferon eyedrops. One patient complained of slight nasopharyngeal pain, however serious side effects were not found in all cases. Conclusions:Topical INFα2b is safe and effective therapy and well fitted for ocular reconstruction surgeries to treat CIN and recover ocular surface integrity.
Keywords: tumors • transplantation • drug toxicity/drug effects