May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The relationship between change in visual acuity and the development of clinically significant diabetic macular edema (CSDME).
C. Hudson; T. Wong; K. Guan; M. Kisilevsky; R.K. Nrusimhadevara; J.G. Flanagan
Author Affiliations & Notes
  • C. Hudson
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • T. Wong
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • K. Guan
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • M. Kisilevsky
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • R.K. Nrusimhadevara
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • J.G. Flanagan
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  C. Hudson, Alcon Pharmaceuticals Inc F; T. Wong, None; K. Guan, None; M. Kisilevsky, None; R.K. Nrusimhadevara, None; J.G. Flanagan, Alcon Pharmaceuticals Inc F.
  • Footnotes
    Support  CIHR, PREA, Alcon
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4071. doi:
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      C. Hudson, T. Wong, K. Guan, M. Kisilevsky, R.K. Nrusimhadevara, J.G. Flanagan; The relationship between change in visual acuity and the development of clinically significant diabetic macular edema (CSDME). . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4071.

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Abstract

Abstract: : Purpose: To determine the relationship between change in logMAR visual acuity (VA) and the development of clinically significant diabetic macular edema (CSDME). Methods: The sample comprised 19 patients (7 females and 12 males, mean age 58 years, SD 6.5) with diabetes (type 1 : type 2, 1 : 18, mean duration of diabetes 13.6 years, SD 9.9) enrolled in a prospective study of the natural history of CSDME. The A1c level of the sample prior to conversion to CSDME ranged from 0.065 to 0.139 (mean 0.09, SD 0.02). All 19 patients developed CSDME over the course of the study (independently confirmed by two retinal specialists using contact lens stereo fundus biomicroscopy). Patients were examined at 6 to 2 monthly intervals and were experienced in VA assessment. VA was measured in the eye with CSDME using 96% contrast ETDRS logMAR visual acuity charts illuminated to 100cdm–2. Results: Group mean VA prior to conversion was 0.01 (SD 0.08, range –0.12 to +0.16) and at conversion was 0.06 (SD 0.18, range –0.08 to +0.54). Although the change in VA exceeded +0.30 log units for 2 patients, the difference in group mean VA prior to, and at, conversion was not statistically significant. There was no significant correlation between A1c level and change in VA (r = 0.31, p = 0.20). Conclusions:The development of CSDME fails to result in a group mean change of VA, although a small proportion of individuals may demonstrate a significant decline of VA. VA should not be regarded as a valid outcome measure to assess the impact of treatment trials of new therapeutic agents for CSDME.

Keywords: diabetic retinopathy • visual acuity • clinical (human) or epidemiologic studies: natural history 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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