Retinal Vascular Integrity Following Correction of Diabetic Ketoacidosis in Children and Adolescents

Abstract

Abstract: : Purpose:Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Diabetic retinopathy has been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following correction of DKA. Methods:Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 hours after correction of severe DKA (pH < 7.2). Results:None of the patients had clinical, photographic or angiographic evidence of a retinal abnormality. Conclusions:The blood–retinal barrier (BRB) does not experience perturbation and unlike the blood–brain barrier (BBB) may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison to the BBB.

Keywords: diabetes • retina • blood supply