May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Vitoreous levels of angiopoietin2 and vascular endothelial growth factor of patients with proliferative diabetic retinopathy
M. Kurimoto; H. Takagi; D. Watanabe; K. Suzuma; I. Suzuma; H. Ohashi; T. Ojima; E. Suganami; T. Murakami; Y. Honda
Author Affiliations & Notes
  • M. Kurimoto
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • H. Takagi
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • D. Watanabe
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • K. Suzuma
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • I. Suzuma
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • H. Ohashi
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • T. Ojima
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • E. Suganami
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • T. Murakami
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • Y. Honda
    Department of Ophthalmology, Kyoto Univ Grad Sch of Med, Sakyo, Japan
  • Footnotes
    Commercial Relationships  M. Kurimoto, None; H. Takagi, None; D. Watanabe, None; K. Suzuma, None; I. Suzuma, None; H. Ohashi, None; T. Ojima, None; E. Suganami, None; T. Murakami, None; Y. Honda, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4160. doi:
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      M. Kurimoto, H. Takagi, D. Watanabe, K. Suzuma, I. Suzuma, H. Ohashi, T. Ojima, E. Suganami, T. Murakami, Y. Honda; Vitoreous levels of angiopoietin2 and vascular endothelial growth factor of patients with proliferative diabetic retinopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4160.

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Abstract

Abstract: : Purpose:To investigate the levels of angiopoietin–2 (Ang2) and vascular endothelial growth factor (VEGF) in the vitreous of patients with diabetic retinopathy. Methods:The levels of Ang2 and VEGF were measured by enzyme–linked immunosorbent assay in the vitreous of 56 eyes of 52 patients who underwent vitrectomy with proliferative diabetic retinopathy (40 eyes of 37 patients) and nondiabetic ocular diseases (16 eyes of 15 patients). Nondiabetic control eyes included 10 with idiopathic macular hole, 6 with idiopathic epiretinal membrane. The classification of diabetic retinopathy into active stages and inactive stages was made on the basis of clinical data. Results:Vitreous level of Ang2 was significantly higher in patients with proliferative diabetic retinopathy (1742 ± 3263 pg/ml ) than in nondiabetic patients (102 ± 106 pg/ml )(p = 0.004). For 40 eyes with diabetic retinopathy, vitreous level of Ang2 was significantly higher in the 22 eyes with active proliferative diabetic retinopathy (2945 ± 4180 pg/ml ) than in the 18 eyes with inactive proliferative diabetic retinopathy (417 ± 317 pg/ml). The vitreous concentration of VEGF was also significantly higher in patients with proliferative diabetic retinopathy than in nondiabetic patients (p = 0.0063). Vitreous level of VEGF was significantly higher in the 22 eyes with active proliferative diabetic retinopathy (1124 ± 1111 pg/ml pg/ml ) than in the 18 eyes with inactive proliferative diabetic retinopathy (172 ± 192 pg/ml). The vitreous concentration of Ang2 was correlated with that of VEGF in eyes with proliferative diabetic retinopathy (p = 0.0001, ρ= 0.643). Conclusions:We found the levels of both Ang2 and VEGF were elevated in the vitreous fluid of patients with proliferative diabetic retinopathy, which suggests both Ang2 and VEGF are related to angiogenesis in proliferative diabetic retinopathy.

Keywords: diabetic retinopathy • retinal neovascularization • growth factors/growth factor receptors 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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