Electrical stimulation with a needle type electrode placed into the optic disc in rabbit eyes.

Abstract

Abstract: : Purpose: To examine if electrical stimulation in the optic disc can elicit an electrical evoked potential (EEP) in rabbits and if it is an effective approach for placing a visual prosthesis. Methods: Two needle type electrodes were placed in the optic disc. Either monophasic or biphasic pulse was used for electrical stimulation. When stimulating the optic disc, the EEP was investigated. After examination of the EEP, histological study was performed. Results: We developed a new, safe approach for placing a needle type electrode into the optic disc. When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10±0 µA and 20±8.2 µA (0.5 msec), respectively. Histological examination demonstrated that no damage was caused from the electrical stimulation. Conclusions: Electrical stimulation of the optic disc can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system.

Keywords: optic disc • electrophysiology: non–clinical