May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Epiretinal fixation of the polyimide electrode array using silicon retinal tack
Author Affiliations & Notes
  • H. Chung
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • J.–M. Seo
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • S.–J. Paik
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
    Seoul National University School of Electrical Engineering and Computer Science, Seoul, Republic of Korea
  • D. Cho
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
    Seoul National University School of Electrical Engineering and Computer Science, Seoul, Republic of Korea
  • E. Kim
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
    Seoul National University School of Electrical Engineering and Computer Science, Seoul, Republic of Korea
  • S. Kim
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
    Seoul National University School of Electrical Engineering and Computer Science, Seoul, Republic of Korea
  • K. Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • J. Heo
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • H.G. Yu
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • Y.S. Yu
    Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center (SAEC), Seoul, Republic of Korea
    Nano Bioelectronics & System Research Center (NBS–ERC), Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  H. Chung, None; J. Seo, None; S. Paik, None; D. Cho, None; E. Kim, None; S. Kim, None; K. Kim, None; J. Heo, None; H.G. Yu, None; Y.S. Yu, None.
  • Footnotes
    Support  MOST; NBS–ERC
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4182. doi:
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      H. Chung, J.–M. Seo, S.–J. Paik, D. Cho, E. Kim, S. Kim, K. Kim, J. Heo, H.G. Yu, Y.S. Yu; Epiretinal fixation of the polyimide electrode array using silicon retinal tack . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4182.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Silicon–micromachined retinal tacks were developed for the fixation of the epiretinal–type retina–stimulating microelectrode array. To evaluate the usability and durability of the silicon retinal tack, in vivo experiments were done. Methods: Silicon retinal tacks were fabricated by using the SBM (Sacrificial Bulk Micromachining) technology, which is a method of releasing silicon structures in a (111) oriented silicon wafer. The dimensions of the retinal tack were 1.5 mm long, 150 µm wide, and 150 µm thick, which are substantially smaller than those of the conventional titanium tack. The tapered tip of the retinal tack made the insertion of the retinal tack easy, and the barbed–wire on the retinal tack shank made the fixation of the electrode array strong. To enhance the durability and the long–term biocompatibility of the retinal tack, 3 µm–thick parylene film was deposited on the entire surfaces uniformly. In vivo experiments were performed in the eyes of anesthetized rabbits. After 3–port pars planar vitrectomy, a polyimide electrode array was introduced into the vitreous cavity through sclerotomy site with vitreous forceps. With a 30 gauge needle, the target sites, where the retinal tacks were located, were marked from inside of the eye. Silicon retinal tack was introduced into the vitreous cavity and the electrode array was fixed by using the silicon tack. After the operation, inflammatory reaction and histological change of the eyes were evaluated. Results: Twenty implantation experiments of fixing the polyimide electrode with the silicon retinal tack in the rabbit's eye were performed. After the epiretinal implantation of the polyimide electrode array and the silicon retinal tack, the implanted devices did not move or become loose. Inflammatory change was not observed in the rabbit eye for more than 2 months, except a minute glial cell proliferation found around the retinal tack on the histological examination. Conclusions:The silicon retinal tack is a good device to fix delicate epiretinal prosthetic devices in vivo. Investigations into the long–term stability and the glial cell proliferation around the tack are necessary.

Keywords: retina • degenerations/dystrophies • transplantation 
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