May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
EVALUATION OF AN INACTIVE EPIRETINAL POLY–DIMETHYLSILOXANE ELECTRODE ARRAY IMPLANTED IN DOGS BY OPTICAL COHERENCE TOMOGRAPHY
Author Affiliations & Notes
  • D. Guven
    Ophthalmology, Doheny Retina Institute,USC Keck School of Medicine, Los Angeles, CA
  • M. Maghribi
    Lawrence Livermore National Laboratory (LLNL), Livermore, CA
  • J.D. Weiland
    Ophthalmology, Doheny Retina Institute,USC Keck School of Medicine, Los Angeles, CA
  • C. Davidson
    Lawrence Livermore National Laboratory (LLNL), Livermore, CA
  • S. Pannu
    Lawrence Livermore National Laboratory (LLNL), Livermore, CA
  • S. Arai
    Ophthalmology, Doheny Retina Institute,USC Keck School of Medicine, Los Angeles, CA
  • P. Krulevitch
    Lawrence Livermore National Laboratory (LLNL), Livermore, CA
  • L. LaBree
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA
  • M.S. Humayun
    Ophthalmology, Doheny Retina Institute,USC Keck School of Medicine, Los Angeles, CA
  • Footnotes
    Commercial Relationships  D. Guven, None; M. Maghribi, None; J.D. Weiland, None; C. Davidson, None; S. Pannu, None; S. Arai, None; P. Krulevitch, None; L. LaBree, None; M.S. Humayun, None.
  • Footnotes
    Support  DOE grant # 6400001599/11733,NEI grant EY03040,The Fletcher JonesFoundation,ResearchtoPrevent Blindn
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4213. doi:
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      D. Guven, M. Maghribi, J.D. Weiland, C. Davidson, S. Pannu, S. Arai, P. Krulevitch, L. LaBree, M.S. Humayun; EVALUATION OF AN INACTIVE EPIRETINAL POLY–DIMETHYLSILOXANE ELECTRODE ARRAY IMPLANTED IN DOGS BY OPTICAL COHERENCE TOMOGRAPHY . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4213.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: In the development and design of epiretinal microelectronic arrays, the distance between the electrodes and the target tissue is important since it can influence the efficacy of electrical stimulation. In this study, we used optical coherence tomography(OCT) to evaluate the proximity of a new epiretinal array to the retina and its effect on the retina. Methods: Second generation poly(dimethylsiloxane)(PDMS)–based microelectrode arrays with dimensions of 4mmx40mmx55–60um were designed and manufactured by soft lithography by LLNL. The device contained strengthening micromolded ribs and a retinal tack hole. The implanted animals were followed up by photography, fluorescein angiography(FA) and OCT. Single line scan protocol and retinal thickness analysis were used to measure the retinal thickness and the distance between the array and the retinal surface. Peripapillary retinal nerve fiber layer(RNFL) thickness was evaluated by circular scan. Results: Following pars plana vitrectomy and removal of the posterior hyaloid,implantation of the arrays were performed in 4 dogs consecutively. The flexible ribbon–like array was placed onto the superotemporal retina. The PDMS array contained 4–8 passivated gold electrodes 300 um in diameter. One retinal tack was sufficient to fix the array in place. During the follow–up period of 2, 2, 4 and 5 months respectively,close contact of the array with the retina was shown using OCT. Baseline retinal thickness at the area centralis was 205±7um. The mean distance between the array and the underlying retina and mean retinal thickness under the array were 33±42 um (n=3), 214±14um (n=4) at the 1st month, 72±63um, 200±17um (n=4) at the 2nd month, 48±52um, 194±21um (n=2) at the 3rd month, 28±30um, 188±3um (n=2) at the 4th month and 180um, 57um (n=1) at the 5th month. Follow–up of the first dog discontinued at the 2nd month due to a retinal detachment. Peripapillary RNFL thickness measurements performed in 2 dogs, revealed no statistically significant difference during the follow–up of 2 and 4 months respectively.(p>0.05) Conclusion: OCT imaging shows that the PDMS epiretinal implant matches to the curvature of inner surface of the retina providing a close proximity to the retina. It enables the evaluation of the retina at and around the implantation site, as a helpful tool in addition to FA and ocular examination.

Keywords: retina • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer 
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