OCT and mf–ERG changes in patients with unilateral central serous retinopathy

Abstract

Abstract: : Purpose:The purpose of this prospective observational study is to determine the OCT and mf–ERG changes in patients with unilateral central serous retinopathy (CSR) at presentation and after the total disappearance of ophthalmologic and fluoroangiographic evidence of the disease. Methods:Twenty–one eyes of 21 patients (mean age 45.25 years) were referred with unilateral impairment of visual acuity, due to CSR. All patients underwent complete ophthalmological examination, which included measurement of best–corrected visual acuity (VA), fundus examination, fluorescein angiography, OCT and mf–ERG recording. Both eyes of each patient were examined at presentation and after the regression of CSR according to the ophthalmoscopic and fluorescein angiographic findings. Results:At presentation, VA of the affected eyes was significantly lower than the VA of the non–affected eyes (p<0.001). The mean retinal thickness of the fovea measured by OCT of the affected eyes was found 31.2% more increased compared to the one of the clinically healthy fellow eye. The mean mf–ERG amplitude of the affected eyes in area 1 demonstrated a decrease of 28.81% compared to the non–affected eyes of our patients. After the regression of CSR, the mean VA of the affected eyes improved but still remained diminished. OCT measurements of the affected eyes remained lower by 7.8% compared to the non–affected eyes of our study group. The mf–ERG amplitude of the affected eyes in area 1 was still decreased by 23.52% compared to the non–affected ones. Conclusions:After the regression of CSR and the absence of ophthalmoscopic and fluorescein angiographic findings, VA improves, but still remains low. OCT and mf–ERG measurements also ameliorate, but mf–ERG remains significantly abnormal.

Keywords: electrophysiology: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea