Abstract
Abstract: :
Purpose: To evaluate objectively the macular function in age related macular degeneration (ARMD) by means of the multifocal electroretinogram (ERG). Methods: Multifocal ERG were obtained using VERIS 5.05 visual evoked response imaging system for 20 patients (40 eyes) with nonexudative ARMD and 20 normal subjects (40 eyes). Burian–Allen contact lens electrode was used to record the responses from 103 retinal locations in 7 min (16 segments). The 31 Hz flicker focal ERGs were recorded with a hand–held stimulator (Maculoscope) in the same patient and the spot light stimuli were 5 degrees at macular region. Results:The latencies of a wave and b wave delayed significantly, the amplitude densities and the amplitude summary of b wave decreased markedly at all rings in ARMD group comparing with normal group(P<0.05). Fifty percent and 90% percent affected eyes showed normal latencies and reduced amplitude densities and amplitude summary of b wave at ring 1 and ring 2 of multifocal ERG respectively, 35% percent and 65% percent affected eyes showed normal latencies and reduced amplitude densities and amplitude summary of b wave at ring 3 and ring 4 of multifocal ERG respectively, 15% percent and 30% percent affected eyes showed normal latencies and reduced amplitude densities and amplitude summary of b wave at ring 5 and ring 6 of multifocal ERG respectively, but 95% affected eyes showed markedly reduced amplitude and delayed latency of 31 Hz flicker focal ERGs. Conclusions:This study suggests multifocal ERG could give much important information about the disturbance of the macular function in ARMD cases than the focal flicker ERG. The advantage and defect between two recording methods in ARMD cases could be discussed.
Keywords: electrophysiology: clinical • adenovirus