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Y.T. Elia, D. Daneman, J. Rovet, M. Abdolell, W.–C. Lam, C. Till, V. Erraguntla, S. Rubab, C.A. Westall; Visual Evoked Potentials to Investigate the Chromatic Mechanisms of Pre–Teen Children with Type I Diabetes . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4337.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:The colour visual evoked potential (VEP) is a sensitive indicator for detecting early colour vision changes in type 1 diabetes. The purpose of this study was to examine the association between short–wavelength VEPs and long–term glucose control (% HbA1c) in pre–teen children with type I diabetes. Methods:Fifty children with type I diabetes, ages 6 to 12.9 years, and 33 age–matched controls were tested. VEPs were recorded according to ISCEV standards. Colour stimuli created to optimize and activate selectively the short–wavelength (S), and long and medium wavelength (LM) pathways were vertical, photometric isoluminant chromatic (1cpd) presented in a pattern onset (100msec)–offset (400msec) mode. The offset mode was a uniform field of same mean chromaticity and luminance (36.50cd/m2) as the onset. Relationship between short–wavelength VEP latency and % HbA1c was determined using ANCOVA regression. Results:Neither short–wavelength VEP nor LM VEP latency was significantly associated with % HbA1c. However, pubertal status (pre–pubertal vs pubertal) was found to be significantly (p=0.0112) and selectively associated with short–wavelength VEP latency. In fact, 53% of the children with diabetes tested were classified as pubertal and had significantly delayed short–wavelength latencies (∼9msec) when compared with the pre–pubertal children with diabetes. Moreover, short–wavelength VEPs did not differ between diabetes and control groups for pre–pubertal children, but there was a significant difference between groups in the pubertal children (diabetes 145.27 +/– 12.24 SD, controls 138.90 +/– 7.03 SD, p<0.05). Conclusions:Puberty rather than metabolic control appears to selectively affect the short–wavelength pathway of children with diabetes. Further study is required to determine whether this pubertal selective reduction in short–wavelength sensitivity changes over time, and whether this change could act as a predictive marker for future development of background diabetic retinopathy in children with type I diabetes.
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