May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Visual Evoked Potentials to Investigate the Chromatic Mechanisms of Pre–Teen Children with Type I Diabetes
Y.T. Elia; D. Daneman; J. Rovet; M. Abdolell; W.–C. Lam; C. Till; V. Erraguntla; S. Rubab; C.A. Westall
Author Affiliations & Notes
  • Y.T. Elia
    Ophthalmology, Institute of Medical Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
    University of Toronto, Toronto, ON, Canada
  • D. Daneman
    Ophthalmology, Institute of Medical Sciences,
    Endocrinology, Department of Public Health Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
    University of Toronto, Toronto, ON, Canada
  • J. Rovet
    Ophthalmology, Institute of Medical Sciences,
    Psychology,
    Hospital for Sick Children, Toronto, ON, Canada
    University of Toronto, Toronto, ON, Canada
  • M. Abdolell
    Endocrinology, Department of Public Health Sciences,
    University of Toronto, Toronto, ON, Canada
    Cancer Quality Council of Ontario Secretariat, Cancer Care Ontario, Toronto, ON, Canada
  • W.–C. Lam
    Ophthalmology, Institute of Medical Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
  • C. Till
    Psychology,
    Hospital for Sick Children, Toronto, ON, Canada
  • V. Erraguntla
    Ophthalmology, Institute of Medical Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
  • S. Rubab
    Ophthalmology, Institute of Medical Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
  • C.A. Westall
    Ophthalmology, Institute of Medical Sciences,
    Hospital for Sick Children, Toronto, ON, Canada
    University of Toronto, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  Y.T. Elia, None; D. Daneman, None; J. Rovet, None; M. Abdolell, None; W. Lam, None; C. Till, None; V. Erraguntla, None; S. Rubab, None; C.A. Westall, None.
  • Footnotes
    Support  VSRP, Toronto Western Hospital Research Institute
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4337. doi:
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      Y.T. Elia, D. Daneman, J. Rovet, M. Abdolell, W.–C. Lam, C. Till, V. Erraguntla, S. Rubab, C.A. Westall; Visual Evoked Potentials to Investigate the Chromatic Mechanisms of Pre–Teen Children with Type I Diabetes . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4337.

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Abstract

Abstract: : Purpose:The colour visual evoked potential (VEP) is a sensitive indicator for detecting early colour vision changes in type 1 diabetes. The purpose of this study was to examine the association between short–wavelength VEPs and long–term glucose control (% HbA1c) in pre–teen children with type I diabetes. Methods:Fifty children with type I diabetes, ages 6 to 12.9 years, and 33 age–matched controls were tested. VEPs were recorded according to ISCEV standards. Colour stimuli created to optimize and activate selectively the short–wavelength (S), and long and medium wavelength (LM) pathways were vertical, photometric isoluminant chromatic (1cpd) presented in a pattern onset (100msec)–offset (400msec) mode. The offset mode was a uniform field of same mean chromaticity and luminance (36.50cd/m2) as the onset. Relationship between short–wavelength VEP latency and % HbA1c was determined using ANCOVA regression. Results:Neither short–wavelength VEP nor LM VEP latency was significantly associated with % HbA1c. However, pubertal status (pre–pubertal vs pubertal) was found to be significantly (p=0.0112) and selectively associated with short–wavelength VEP latency. In fact, 53% of the children with diabetes tested were classified as pubertal and had significantly delayed short–wavelength latencies (∼9msec) when compared with the pre–pubertal children with diabetes. Moreover, short–wavelength VEPs did not differ between diabetes and control groups for pre–pubertal children, but there was a significant difference between groups in the pubertal children (diabetes 145.27 +/– 12.24 SD, controls 138.90 +/– 7.03 SD, p<0.05). Conclusions:Puberty rather than metabolic control appears to selectively affect the short–wavelength pathway of children with diabetes. Further study is required to determine whether this pubertal selective reduction in short–wavelength sensitivity changes over time, and whether this change could act as a predictive marker for future development of background diabetic retinopathy in children with type I diabetes.

Keywords: color vision • diabetes • electrophysiology: clinical 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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