May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Intermediate–term Outcomes for Primary Trabeculectomy with Intraoperative 5–Fluorouracil Versus Mitomycin
R.I. Fish; A.P. Capistrano; D. WuDunn; L. Cantor; J. Hoop; C. Finley; V. Lakhani; N. Alvi
Author Affiliations & Notes
  • R.I. Fish
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • A.P. Capistrano
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • D. WuDunn
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • L. Cantor
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • J. Hoop
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • C. Finley
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • V. Lakhani
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • N. Alvi
    Ophthalmology, INDIANA UNIVERSITY, Indianapolis, IN
  • Footnotes
    Commercial Relationships  R.I. Fish, None; A.P. Capistrano, None; D. WuDunn, None; L. Cantor, None; J. Hoop, None; C. Finley, None; V. Lakhani, None; N. Alvi, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4389. doi:
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      R.I. Fish, A.P. Capistrano, D. WuDunn, L. Cantor, J. Hoop, C. Finley, V. Lakhani, N. Alvi; Intermediate–term Outcomes for Primary Trabeculectomy with Intraoperative 5–Fluorouracil Versus Mitomycin . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4389.

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Abstract

Abstract: : Purpose: To compare the safety and efficacy of intraoperative 5–FU versus MMC in eyes undergoing primary trabeculectomy Methods: One hundred fifteen eyes of 93 persons (66 ± 12 years) requiring primary trabeculectomy were randomized in a prospective, double–masked fashion to receive either topical intraoperative MMC (0.2mg/cc x 2min) or 5–FU (50mg/cc x 5min). Main outcome variables were success of IOP control, visual acuity, and complications. Success was defined as at least 25% reduction in IOP from baseline, IOP ≤ 21 mmHg with or without medications, and IOP ≥ 6. Major complications and re–operations were considered failures Results: The majority of patients were followed for at least 36 months or until failure occurred. Cumulative survival in the 5–FU group was 0.81 at 24 months and 0.76 at 36 months whereas cumulative survival in the MMC group was 0.76 at 24 months and 0.73 at 36 months (P=0.67, log–rank test). Of the 115 eyes (57 in MMC and 58 in 5–FU), there were a total of 34 failures (18 in MMC group, 16 in 5–FU group). Twenty–three subjects either died or were lost to follow up (12 patients in MMC group and 11 in 5–FU group). Reasons for failure in the 5–FU group included inadequate IOP control in 6 cases, bleb leaks requiring bleb revision in 7 cases, hypotony requiring surgical intervention in 3 cases. Reasons for failure in the MMC group included inadequate IOP control in 3 cases, bleb leak requiring revision in 5 cases, hypotony requiring intervention in 7 cases, endophthalmitis in 2 cases, and bleb dyesthesia requiring revision in 1 case. Twenty four patients in the MMC group and 18 patients in the 5–FU group had cataract surgery during the study period. Conclusions: Our data suggests that 5–FU filtering blebs have similar survival compared to MMC filtering blebs when applied topically according to our protocol. CR: None Support: Supported in part by Research to Prevent Blindness, Inc.

Keywords: intraocular pressure • trabecular meshwork • outflow: trabecular meshwork 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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