May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Pupillographic measurements with pattern stimulation in ocular hypertensives and glaucoma patients
Author Affiliations & Notes
  • B. Link
    Univ. Dept. Ophthalmology, University Erlangen–Nuremberg, Erlangen, Germany
  • K. Dehne
    Univ. Dept. Ophthalmology, University Erlangen–Nuremberg, Erlangen, Germany
  • F. Horn
    Univ. Dept. Ophthalmology, University Erlangen–Nuremberg, Erlangen, Germany
  • M. Korth
    Univ. Dept. Ophthalmology, University Erlangen–Nuremberg, Erlangen, Germany
  • Footnotes
    Commercial Relationships  B. Link, None; K. Dehne, None; F. Horn, None; M. Korth, None.
  • Footnotes
    Support  SFB 539
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4471. doi:
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    • Get Citation

      B. Link, K. Dehne, F. Horn, M. Korth; Pupillographic measurements with pattern stimulation in ocular hypertensives and glaucoma patients . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4471.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Differences in amplitude and velocity of pupil contraction between normal and glaucoma subjects measured have been reported previously. The aim of this study was to investigate pupil reaction in response to pattern onset/offset to detect changes in the pupillomotoric system in glaucoma patients. Methods: A Maxwellian–view system equipped with a Xenon–arc lamp and a mechanical mirror system was used. Complete series of pattern reaction were studied in 3 normal subjects by variation of spatial frequency (0,3; 0,88; 1,22; 2,7; 3,45; 6,25; 9,2 per/°), intensity (0,5–4,0) and contrast (5–100%). Amplitude and latency of both onset– and offset response, maximal velocity and acceleration of contraction were determined. Both eyes of 57 subjects from the Erlangen Glaucoma Registry were studied with pattern onset/offset (spatial frequencies 0,3 per/° and 6,25 per/°, contrast: 100%, white light, duration of one period: 4000 ms, area of field: 32°). Examined eyes included 34 normals, 28 hypertensives, 6 preperimetric glaucomas and 23 perimetric glaucomas (mean MD 5,13). Patients had no previous intraocular surgery, only one patient had LTP previously performed. Normals did not take any antiglaucomatous drugs, as did 8 of the OHT, 4 of the preperimetric OAG and 21 of the perimetric glaucomas. Local antiglaucomatous therapy included prostaglandin–derivates, ß–blockers and acetazolamides. None of the patients received miotic or mydriatic eye–drops. Results: Significant differences (p<0,05) between normals and glaucomas are found in amplitude and velocity of contraction in the onset–response (spatial frequencies 0,3 and 6,25 per/°) and in acceleration in the offset–response (spatial frequencies 0,3 per/°). No statistical differences were found between normals and ocular hypertensives. Conclusions: Results indicate a difference in pattern–pupillography between normals and glaucoma patients mainly in the onset–response. Further investigations will to be conducted to determine the role of pupillography in early glaucoma and on the effect of antiglaucomatous drugs.

Keywords: pupil 
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