May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Baseline Findings in the Glaucoma Imaging Longitudinal Study(GILS)
Y. Ding; H. Jampel; H. Quigley; C. Marks; F. Knezevich; N. Congdon; D. Friedman; S. Vitale; R. Zeimer
Author Affiliations & Notes
  • Y. Ding
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • H. Jampel
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • H. Quigley
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • C. Marks
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • F. Knezevich
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • N. Congdon
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • D. Friedman
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • S. Vitale
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD
  • R. Zeimer
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships  Y. Ding, None; H. Jampel, None; H. Quigley, None; C. Marks, None; F. Knezevich, None; N. Congdon, None; D. Friedman, None; S. Vitale, None; R. Zeimer, Talia Technologies P.
  • Footnotes
    Support  NIH grant EY R01–12295
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4484. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Baseline Findings in the Glaucoma Imaging Longitudinal Study(GILS)
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Y. Ding, H. Jampel, H. Quigley, C. Marks, F. Knezevich, N. Congdon, D. Friedman, S. Vitale, R. Zeimer; Baseline Findings in the Glaucoma Imaging Longitudinal Study(GILS) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4484.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To describe baseline associations between structuraland functional glaucoma parameters in patients in the GlaucomaImaging Longitudinal Study (GILS), an evaluation of disc andmacular imaging modalities in detecting glaucoma progression.Methods: Subjects underwent SITA Fast visual field (VF) testing,optic disc imaging (HRT II, Heidelberg Instruments, Heidelberg,Germany), ophthalmic exam by a glaucoma specialist, stereo fundusphotography, and macular retinal thickness measurement (RTA1999 version, Talia Technologies, Neve Ilan, Israel). We analyzedHRT cup shape and rim area and RTA mean retinal thickness lossrelative to normal eyes (derived from a custom Matlab program)in the superior and inferior perifoveal regions.Results: 310 eyes of 205 subjects (ages 53–92 y, mean,69 y) had reliable baseline VF tests (fixation losses < 30%and false positive responses < 15%). 45% were female and18% were of African–American descent. 260 eyes of 173subjects had adequate quality HRT scans (topographical standarddeviation < 50) and 163 eyes of 121 subjects had adequatequality RTA scans (greater than 75% of points measurable). Averagemean deviation was –9.7 dB. Association between macularretinal thickness loss and central VF loss 

Image not available
View OriginalDownload Slide
Image not available
View OriginalDownload Slide
Association between disc rim area and VF loss 
Image not available
View OriginalDownload Slide
Image not available
View OriginalDownload Slide
Conclusions: We found relatively more severe inferior perifovealthickness loss than VF loss (60 vs. 37 eyes) and relativelymore severe disc rim area loss than VF loss (101 vs. 71 eyes).The GILS study will be able to evaluate whether these eyes withmacular and disc changes that are relatively more severe thanVF loss are at increased risk of VF progression over time.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • imaging/image analysis: clinical • ganglion cells 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept